Results 101 to 110 of about 3,321,094 (294)

A new mixture model approach to analyzing allelic-loss data using Bayes factors

BMC Bioinformatics, 2004
Background Allelic-loss studies record data on the loss of genetic material in tumor tissue relative to normal tissue at various loci along the genome.
Emond Mary J, Desai Manisha
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Pharmacological Inhibition of DNA Methylation Induces Proinvasive and Prometastatic Genes In Vitro and In Vivo

Neoplasia: An International Journal for Oncology Research, 2008
The mechanism of action of DNA methylation inhibitor 5-aza-2′-deoxycytidine (5-aza-CdR), a potential anticancer agent is believed to be activated by the demethylation of tumor suppressor genes. We tested here the hypothesis that demethylating agents also
Bushra Ateeq, Alexander Unterberger, Moshe Szyf, Shafaat A Rabbani   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Significance of clustered tumor suppressor genes in cancer

, 2012
Evaluation of: Xue W, Kitzing T, Roessler S et al. A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proc. Natl Acad. Sci. USA 109, 8212-8217 (2012).
S.M. Sirchia, M. Miozzo
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]

, 2002
Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, Burkhard, Göke, B., Kolligs, Frank T, Bommer, Guido, Kolligs, F. T.   +5 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Cluster Analysis of Tumor Suppressor Genes in Canine Leukocytes Identifies Activation State

, 2015
Cells of the immune system undergo activation and subsequent proliferation in the normal course of an immune response. Infrequently, the molecular and cellular events that underlie the mechanisms of proliferation are dysregulated and may lead to ...
Sally-Anne Mortlock, Daly, Julie-Anne, Williamson, Peter, Peter Williamson, Taylor, Rosanne M., Julie-Anne Daly, Rosanne M. Taylor, Mortlock, Sally-Anne   +7 more
core   +1 more source

Crosstalk between c-Jun and TAp73alpha/beta contributes to the apoptosis–survival balance [PDF]

, 2011
The p53-family member p73 plays a role in various cellular signaling pathways during development and growth control and it can have tumor suppressor properties. Several isoforms of p73 exist with considerable differences in their function.
Simon J. van Heeringen, Smeenk, L., Smeenk, Leonie, Hartmann, Marianne, Eva Janssen-Megens, Lohrum, Marion, Koeppel, M., Heeringen, S.J. van, Hendrik G. Stunnenberg, Daniela Kramer, Hartmann, M., Lohrum, M., Stunnenberg, H.G., Stunnenberg, Hendrik G., Max Koeppel, Kramer, D., Leonie Smeenk, Koeppel, Max, Kramer, Daniela, Janssen-Megens, Eva, Heeringen, Simon J. van, Janssen-Megens, E.M., Marion Lohrum, Marianne Hartmann   +23 more
core   +1 more source