Results 81 to 90 of about 342,913 (296)

Identification of Methylated Genes Associated with Aggressive Clinicopathological Features in Mantle Cell Lymphoma

, 2011
Background: Mantle cell lymphoma (MCL) is genetically characterized by the t(11;14)(q13;q32) translocation and a high number of secondary chromosomal alterations. The contribution of DNA methylation to MCL lymphomagenesis is not well known.
Campo Elías, Fernandez, Veronica, Sílvia Beà, Magda Pinyol, Hernández Luis, Beà Bobet, Sílvia M., Fernàndez Verònica, Jares, Pedro, Anna Enjuanes, Andreas Rosenwald, Pinyol Magda, Verònica Fernàndez, Rosenwald, Andreas, Pinyol, Magda, Pedro Jares, German Ott, López-Guillermo Armando, Enjuanes Anna, Bea, Silvia, Hernández, Luis, López Guillermo, Armando, Beà Sílvia, Rosenwald Andreas, Fernàndez Pascual, Verònica, Armando López-Guillermo, Navarro, Alba, Jares Pedro, Lopez-Guillermo, Armando, Ott, German, Jares Gerboles, Pedro, Luis Hernández, Campo Güerri, Elias, Navarro Alba, Elías Campo, Campo, Elias, Alba Navarro, Enjuanes, Anna, Ott German   +37 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The role of histone deacetylases in human gastrointestinal and associated glands cancer [PDF]

Journal of Advanced Biomedical Sciences, 2019
Background & Objective: In the eukaryotic cells, the DNA wraps around the histone proteins (H2A, H2B, H3, and H4) and constitutes the nucleosome. Chromatin organization plays a major role in the control of gene expression.
Masumeh Sanaei, Fraidoon Kavoosi
doaj  

Promoter hypermethylation of p16 and APC in gastrointestinal cancer patients

The Turkish Journal of Gastroenterology, 2014
Background/Aims: Cancer is a consequence of the disruption of cellular regulation. Epigenetic is one of the reasons of this disruption. Epigenetic factors play a role in the carcinogenesis by affecting proto-oncogenes and tumor suppressor genes and it is
Beril Erdem, Sibel Küçükyıldırım, Emel Sağlar, Zülfikar Polat, Hatice Mergen   +4 more
doaj   +1 more source

A global view of the oncogenic landscape in nasopharyngeal carcinoma : an integrated analysis at the genetic and expression levels [PDF]

, 2012
Previous studies have reported that the tumour cells of nasopharyngeal carcinoma (NPC) exhibit recurrent chromosome abnormalities. These genetic changes are broadly assumed to lead to changes in gene expression which are important for the pathogenesis of
Aicha Amari, Murray, Paul G, Dawson, Christopher W, Wei, Wenbin, Xiaoyi Chen (150873), Sim K. Sihota (150887), Shao, Jian-Yong, Andrew I Bell, Maloney, S.L., Nicholls, John M, Shao, J.Y., Aicha Amari (150894), Hu, C., K Dalia Derkaoui, Stephanie L Maloney, Wei, W., Arrand, J.R., Wenbin Wei (150871), Woodman, C.B., Sihota, Sim K, Murray, P.G., Ciaran B. Woodman (150878), Derkaoui, K.D., Ciaran B Woodman, Jian-Yong Shao (41845), Maloney, Stephanie L., Bell, Andrew I., Dawson, Christopher W., John M. Nicholls (150882), Derkaoui, K Dalia, Derkaoui, K. Dalia, Maloney, Stephanie L, Bell, A.I., Sihota, Sim K., Xiaoyi Chen, Lawrence S. Young (150912), Woodman, Ciaran B. J., Nicholls, J.M., Arrand, J. R. (John R.), Irène Joab (150885), Joab, Irène, Amari, Aicha, Arrand, John R, Woodman, Ciaran B, Wenbin Wei, Paul G. Murray (150907), Christopher W. Dawson (150910), Chen, X., Yao, Yunhong, Chunfang Hu, Dawson, C.W., Chunfang Hu (150868), K. Dalia Derkaoui (150892), Andrew I. Bell (150904), Chen, Xiaoyi, Young, Lawrence S., Joab, I., John R. Arrand (150915), Irène Joab, Christopher W Dawson, Nicholls, J. M. (John M.), Stephanie L. Maloney (150899), Yunhong Yao, Wei, Wenbin; id_orcid, Young, Lawrence S, Lawrence S Young, John R Arrand, John M Nicholls, Paul G Murray, Amari, A., Jian-Yong Shao, Bell, Andrew I; id_orcid, Yao, Y., Yunhong Yao (150880), Hu, Chunfang, Young, L.S., Sihota, S.K., Murray, Paul G., Sim K Sihota   +78 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Identification of tumor suppressor genes via cell fusion and chromosomal transfer

, 2012
Non
Hong Lok, Hong Lok Lung, Cheng, Y, Arthur Kwok Leung Cheung, Lung, ML, Maria Li, Cheung, AKL, Ko, JMY, Yue Cheng, Josephine Mun Yee Ko, Maria Li Lung, Lung, HL   +11 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Prognostic significance of mutated genes in megakaryocytic disorders

Oncology Reviews, 2019
Megakaryopoiesis is a process during which platelets that play a major role in hemostasis are produced due to differentiation and maturation of megakaryocytic precursors.
Ali Amin Asnafi, Mohammad bagher Mohammadi, Hadi Rezaeeyan, Nader Davari, Najmaldin Saki   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source