Results 241 to 250 of about 481,131 (293)
Some of the next articles are maybe not open access.
Neuron, 1991
For the past decade, cellular oncogenes have attracted the attention of biologists intent on understanding the molecular origins of cancer. As the present decade unfolds, oncogenes are yielding their place at center stage to a second group of actors, the tumor suppressor genes, which promise to teach us equally important lessons about the molecular ...
+10 more sources
For the past decade, cellular oncogenes have attracted the attention of biologists intent on understanding the molecular origins of cancer. As the present decade unfolds, oncogenes are yielding their place at center stage to a second group of actors, the tumor suppressor genes, which promise to teach us equally important lessons about the molecular ...
+10 more sources
Current Opinion in Genetics & Development, 1994
The mutation of tumor suppressor genes is thought to contribute to tumor growth by inactivating proteins that normally act to limit cell proliferation. Several tumor suppressor proteins have been identified in recent years, but only two of them, p53 and pRb, are understood in detail.
P W, Hinds, R A, Weinberg
openaire +3 more sources
The mutation of tumor suppressor genes is thought to contribute to tumor growth by inactivating proteins that normally act to limit cell proliferation. Several tumor suppressor proteins have been identified in recent years, but only two of them, p53 and pRb, are understood in detail.
P W, Hinds, R A, Weinberg
openaire +3 more sources
Current Opinion in Genetics & Development, 2000
Although tumor suppressor genes continue to be discovered, the most recent advances have been made in attributing new and exciting functions to existing ones - such as the apparent role of VHL as a regulator of proteolysis. Great insights have also come from piecing genes together into pathways and networks. For instance the discovery that cyclin D1 is
Tracey L. Plank, Elizabeth Petri Henske
openaire +3 more sources
Although tumor suppressor genes continue to be discovered, the most recent advances have been made in attributing new and exciting functions to existing ones - such as the apparent role of VHL as a regulator of proteolysis. Great insights have also come from piecing genes together into pathways and networks. For instance the discovery that cyclin D1 is
Tracey L. Plank, Elizabeth Petri Henske
openaire +3 more sources
Current Opinion in Genetics & Development, 2005
OVCA1, also known as DPH2L1, is a tumor suppressor gene associated with ovarian carcinoma and other tumors. Ovca1 homozygous mutant mice die at birth with developmental delay and cell-autonomous proliferation defects. Ovca1 heterozygous mutant mice are tumor-prone but rarely develop ovarian tumors.
Chun-Ming, Chen, Richard R, Behringer
openaire +2 more sources
OVCA1, also known as DPH2L1, is a tumor suppressor gene associated with ovarian carcinoma and other tumors. Ovca1 homozygous mutant mice die at birth with developmental delay and cell-autonomous proliferation defects. Ovca1 heterozygous mutant mice are tumor-prone but rarely develop ovarian tumors.
Chun-Ming, Chen, Richard R, Behringer
openaire +2 more sources
Genes, Chromosomes and Cancer, 1998
The FRA3B at 3p14.2 is the most common of the constitutive aphidicolin-inducible fragile sites. Using independent approaches, four groups of investigators have cloned and characterized this fragile site. The results of these studies have revealed that the FRA3B differs from other heretofore cloned rare fragile sites. First, instability as manifested by
M M, Le Beau +6 more
openaire +2 more sources
The FRA3B at 3p14.2 is the most common of the constitutive aphidicolin-inducible fragile sites. Using independent approaches, four groups of investigators have cloned and characterized this fragile site. The results of these studies have revealed that the FRA3B differs from other heretofore cloned rare fragile sites. First, instability as manifested by
M M, Le Beau +6 more
openaire +2 more sources
Tumor suppressor genes in urologic tumors
Urology, 1993During the last decade remarkable progress has been made in our understanding of the malignant phenotype. There is evidence that a series of genetic changes are involved in the conversion of a normal cell to a malignant one. These changes have been directly identified with mutations in various genes usually involved in cell growth and proliferation ...
J M, Wolff, F K, Habib
openaire +2 more sources
The Biomedical & Life Sciences Collection, 2016
A tumor suppressor gene is a type of cancer gene that is created by a loss-of-function mutation. In contrast to the activating mutations that generate oncogenic alleles from proto-oncogene precursors, tumor suppressor genes and the proteins they encode are functionally inactivated by mutations.
openaire +1 more source
A tumor suppressor gene is a type of cancer gene that is created by a loss-of-function mutation. In contrast to the activating mutations that generate oncogenic alleles from proto-oncogene precursors, tumor suppressor genes and the proteins they encode are functionally inactivated by mutations.
openaire +1 more source