Results 251 to 260 of about 481,131 (293)
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BioEssays, 1990
AbstractThe retinoblastoma sensitivity protein (Rb) and the p53 gene product both appear to function as negative regulators of cell division or abnormal cellular growth in some differentiated cell types. Several types of cancers have been shown to be derived from cells that have extensively mutated both alleles of one or both of these genes, resulting ...
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AbstractThe retinoblastoma sensitivity protein (Rb) and the p53 gene product both appear to function as negative regulators of cell division or abnormal cellular growth in some differentiated cell types. Several types of cancers have been shown to be derived from cells that have extensively mutated both alleles of one or both of these genes, resulting ...
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2003
Recent advances in genetics, molecular biology, and molecular pharmacology have resulted in the development of molecularly targeted therapies. Targeting specific molecular pathways essential for the survival of cancer cells would personalize treatment with the potential to improve outcome and minimize toxicities.
Jack A, Roth, Susan F, Grammer
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Recent advances in genetics, molecular biology, and molecular pharmacology have resulted in the development of molecularly targeted therapies. Targeting specific molecular pathways essential for the survival of cancer cells would personalize treatment with the potential to improve outcome and minimize toxicities.
Jack A, Roth, Susan F, Grammer
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Annual Review of Biochemistry, 1993
THE ORIGINS OF THE CONCEPT OF TUMOR SUPPRESSOR GENES . . . . . . . 623 THE PROPERTIES OF ONCOGENES AND TUMOR SUPPRESSOR GENES . . 627 THE ONCOGENES OF THE DNA TUMOR VIRUSES TARGET THE MAJOR CELLULAR TUMOR SUPPRESSOR GENES 629 THE RETINOBLASTOMA SUSCEPTIBILITY GENE AND PROTEIN ........
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THE ORIGINS OF THE CONCEPT OF TUMOR SUPPRESSOR GENES . . . . . . . 623 THE PROPERTIES OF ONCOGENES AND TUMOR SUPPRESSOR GENES . . 627 THE ONCOGENES OF THE DNA TUMOR VIRUSES TARGET THE MAJOR CELLULAR TUMOR SUPPRESSOR GENES 629 THE RETINOBLASTOMA SUSCEPTIBILITY GENE AND PROTEIN ........
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Annual Review of Genetics, 1990
INTRODUCTION . . . , ... ,", .. ", .... ,',', .... ", ..... , ...... " .... ,', .... ,' .. """, ... "" ....... '" 616 SOMATIC CELL HYBRID STUDIES . . . . . . . ... . . .. . . . . . . . . . . , 616 Specific Chromos,?me are Asso iated with Control of Tumorlgemc ExpressIOn . . . .
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INTRODUCTION . . . , ... ,", .. ", .... ,',', .... ", ..... , ...... " .... ,', .... ,' .. """, ... "" ....... '" 616 SOMATIC CELL HYBRID STUDIES . . . . . . . ... . . .. . . . . . . . . . . , 616 Specific Chromos,?me are Asso iated with Control of Tumorlgemc ExpressIOn . . . .
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Head & neck, 1992
Tumor suppressor genes are negative regulators of cell growth. When their normal function is compromised, absence of their inhibitory effects can lead to unrestrained cell cycling and growth. Strong evidence now confirms that loss of proper function of these genes is a common occurrence leading to cancer.
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Tumor suppressor genes are negative regulators of cell growth. When their normal function is compromised, absence of their inhibitory effects can lead to unrestrained cell cycling and growth. Strong evidence now confirms that loss of proper function of these genes is a common occurrence leading to cancer.
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Molekuliarnaia biologiia, 1998
This is an oversimplification of the myriad of molecular functions under the control of these genes. Proto-oncogenes,as we discussed in the last chapter, encode for proteins in the cell signaling pathway and apoptosis. When mutated into oncogenes, their function results in an unregulated stimulation of cell division. Mutated oncogenes act in a dominant
A V, Baranova, N K, Iankovskiĭ
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This is an oversimplification of the myriad of molecular functions under the control of these genes. Proto-oncogenes,as we discussed in the last chapter, encode for proteins in the cell signaling pathway and apoptosis. When mutated into oncogenes, their function results in an unregulated stimulation of cell division. Mutated oncogenes act in a dominant
A V, Baranova, N K, Iankovskiĭ
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2009
Any of a category of genes that can suppress transformation or tumorigenicity (probably ordinarily involved in normal control of cell growth and division).
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Any of a category of genes that can suppress transformation or tumorigenicity (probably ordinarily involved in normal control of cell growth and division).
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2021
This chapter describes the tumor suppressor genes and retinoblastoma gene. It emphasizes that the human body has mechanisms exerted by tumor suppressor genes that normally “police” the processes that regulate cell numbers and ensure that new cells receive DNA that has been precisely replicated.
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This chapter describes the tumor suppressor genes and retinoblastoma gene. It emphasizes that the human body has mechanisms exerted by tumor suppressor genes that normally “police” the processes that regulate cell numbers and ensure that new cells receive DNA that has been precisely replicated.
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Brain and other central nervous system tumor statistics, 2021
Ca-A Cancer Journal for Clinicians, 2021Kimberly D Miller +2 more
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