Results 271 to 280 of about 2,657,421 (309)

Tumor antigen targets and tumor immunotherapy

Frontiers in Bioscience, 2006
Tumor immunology and immunotherapy attempt to use the exquisite specificity and lytic capability of the immune system to treat malignant disease with a minimum of damage to normal tissue. Increasing knowledge of the identity of tumor antigens should point the way to effective therapeutic vaccines or more specific immunotherapeutic strategies.
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Branched Neurotensin for Tumor Targeting

2010
Introduction One of the major problems in classic chemotherapy is the non-specific toxicity of most anticancer agents against normal cells. The specific targeting of tumors has been the main challenge in research on cancer therapy and diagnosis.
FALCIANI C., FABRINI M., LELLI B., LOZZI L., PINI A., BRACCI L.   +5 more
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Immunotherapy of tumor by targeting angiogenesis

Science in China Series C, 2004
Tumor growth and metastasis are angiogenesis-dependent. Anti-angiogenic therapy represents a new strategy for the development of anti-cancer therapies. In recent years, there has been made great progress in anti-angiogenic therapy. As far as the passive immunotherapy is concerned, a recombinant humanized antibody to vascular endothelial growth factor ...
Jianmei, Hou, Ling, Tian, Yuquan, Wei
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Targeted Tumor Therapies at a Glance

Current Drug Targets, 2009
Conventional tumor therapy is usually based on surgery, radiation and chemotherapy. Treatment with chemotherapeutics is often impeded by dose-limiting toxicities. Therefore, medical scientists sought for tools to improve chemotherapy by directly coupling targeting molecules to cytotoxic substances.
H, Fuchs, C, Bachran
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Fibronectin as target for tumor therapy

International Journal of Cancer, 2005
During cancer progression, the extracellular matrix (ECM) of the tissue in which the tumor grows is extensively remodeled, both by degradation of preexisting ECM molecules and by the neosynthesis of ECM components, which in many cases are not present in the ECM of normal tissues. Fibronectin (FN), a class of high-molecular-weight adhesive glycoproteins,
Kaspar M, Zardi L, Neri D
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Tumor‐Targeted Catalytic Immunotherapy

Advanced Materials
Abstract Cancer immunotherapy holds significant promise for improving cancer treatment efficacy; however, the low response rate remains a considerable challenge. To overcome this limitation, advanced catalytic materials offer potential in augmenting catalytic immunotherapy by modulating the immunosuppressive tumor microenvironment ...
En‐Li Yang, Wu‐Yin Wang, Ying‐Qi Liu, Hong Yi, Aiwen Lei, Zhi‐Jun Sun   +5 more
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Angiogenesis as a Target for Tumor Treatment

Oncology, 2009
Angiogenesis is a key step in tumor growth, invasion and metastasis. Thus, antiangiogenic therapy was postulated to be an attractive approach for antitumor treatment. Based on today’s knowledge, at least three strategies for inhibition of angiogenesis are feasible: (1) inhibition of release of angiogenic factors from tumor cells and/or neutralization ...
G, Gastl, T, Hermann, M, Steurer, J, Zmija, E, Gunsilius, C, Unger, A, Kraft   +6 more
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Targeting Tumors

Cancer remains a global health challenge, with conventional treatments often limited by toxicity and specificity. Chimeric Antigen Receptor (CAR) T cell therapy has revolutionized cancer treatment by modifying T cells to target tumor antigens, showing significant success in hematological malignancies like acute lymphoblastic leukemia and diffuse large ...
Safiya Mehraj, Shazia Ali
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Tumor-Targeting Theranostic Polymers

Langmuir
Theranostic polymers have emerged as a versatile platform in cancer nanomedicine, integrating therapeutic and imaging functionalities to overcome challenges in oncology. Featuring diverse architectures such as linear polymers, dendrimers, star-like polymers, and bottle-brush polymers, these systems enable tumor-targeted drug delivery, real-time imaging,
Ying Wei, Mingfeng Wang
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Chemotherapy targeted to tumor vasculature

Current Opinion in Oncology, 1998
Vasculature-targeted chemotherapy--the destruction of tumor blood vessels with cytotoxic agents--makes use of biochemical differences between angiogenic and resting blood vessels. This approach may minimize or eliminate some of the problems associated with conventional solid-tumor targeting, such as poor tissue penetration and drug resistance ...
W, Arap, R, Pasqualini, E, Ruoslahti
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