Results 21 to 30 of about 4,735,472 (312)

Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy [PDF]

, 2009
Background: Glioblastoma is the most frequent and most malignant primary brain tumor with a poor prognosis. The translation of therapeutic strategies for glioblastoma from the experimental phase into the clinic has been limited by insufficient animal ...
Oleg Tsinkalovsky, Euskirchen Philipp, Tsanan Giroglou, Huszthy, Peter C., Giroglou Tsanan, Skaftnesmo, Kai Ove, Miletic, Hrvoje, Miletic Hrvoje, Peter C Huszthy, Kai Ove Skaftnesmo, Tsinkalovsky Oleg, von Laer Dorothee, Euskirchen, Philipp, Dorothee von Laer, Hrvoje Miletic, Laer, Dorothee von, Rolf Bjerkvig, Giroglou, Tsanan, Tsinkalovsky, Oleg, Huszthy Peter C., Skaftnesmo Kai Ove, Bjerkvig Rolf, Philipp Euskirchen, Bjerkvig, Rolf   +23 more
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Somatic gene therapy for cancer. The utility of transferrinfection in generating ‘tumor vaccines’ [PDF]

, 1993
The last few years have seen the development of a branch of somatic gene therapy which aims at strengthening the immune surveillance of the body, leading to eradication of disseminated cancer tumor cells and occult micrometastases after surgical removal ...
Zatloukal, Kurt, Stingl, Georg, Schmidt, Walter, Cotten, Matthew, Wagner, Ernst, Birnstiel, Max L., Cotten, Matt   +6 more
core   +1 more source

Extracellular microparticles derived from hepatic progenitor cells deliver a death signal to hepatoma-initiating cells

Journal of Nanobiotechnology, 2022
The malignant transformation of normal resident hepatic stem/progenitor cells has a critical role in hepatocarcinogenesis and the recurrence of hepatocellular carcinoma (HCC). We defined such hepatic progenitor cells as hepatoma-initiating cells.
Xiaojuan Hou, Wenting Liu, Xue Yang, Changchun Shao, Lu Gao, Li Zhang, Lixin Wei   +6 more
doaj   +1 more source

Intrarectal Foley catheter-assisted high-intensity focused ultrasound ablation for benign uterine diseases beyond the treatment region

International Journal of Hyperthermia, 2023
Objective To evaluate the feasibility of using an intrarectal Foley catheter during ultrasound-guided high-intensity focused ultrasound (US-HIFU) in patients with benign uterine diseases of the posterior wall beyond the HIFU therapeutic range.Methods ...
Wei Liu, Tae-Hee Kim, Lihui Huang, Xing Chen, Chunping Feng, Ling Liu, Li Zhang, Wen Zhang, Kun Zhou, Xiuni Gan   +9 more
doaj   +1 more source

Single-cell microRNA sequencing method comparison and application to cell lines and circulating lung tumor cells

Nature Communications, 2021
Technologies for small non-coding RNA sequencing at the single-cell level are less mature than for sequencing mRNAs. Here the authors evaluate available protocols for analysis of circulating lung cancer tumour cells.
Sarah M. Hücker, Tobias Fehlmann, Christian Werno, Kathrin Weidele, Florian Lüke, Anke Schlenska-Lange, Christoph A. Klein, Andreas Keller, Stefan Kirsch   +8 more
doaj   +1 more source

Generation of X-CGD cells for vector evaluation from healthy donor CD34+ HSCs by shRNA-mediated knock down of gp91phox

Molecular Therapy: Methods & Clinical Development, 2014
Innovative approaches for the treatment of rare inherited diseases are hampered by limited availability of patient derived samples for preclinical research.
Christian Brendel, Kerstin B Kaufmann, Anja Krattenmacher, Shweta Pahujani, Manuel Grez   +4 more
doaj   +1 more source

Response to combination therapy with interferon alfa-2a and ribavirin in chronic hepatitis C according to a TNF-alpha promoter polymorphism [PDF]

, 2003
Background. Tumor necrosis factor-alpha (TNF-alpha) is involved in the pathogenesis of chronic active hepatitis C. Polymorphisms in the promoter region of the TNF-alpha gene can alter the TNF-alpha expression and modify the host immune response.
Konig, A., Folwaczny, Christian, Schmidt, F., Simperl, C., Schaefer, M., Torok, P., Glas, J., Schiemann, Uwe, Martin, K.   +8 more
core   +1 more source

Angiostatic treatment prior to chemo- or photodynamic therapy improves anti-tumor efficacy [PDF]

, 2015
Tumor vasculature is known to be poorly organized leading to increased leakage of molecules to the extravascular space. This process can potentially increase interstitial fluid pressure impairing intra-tumoral blood flow and oxygen supply, and can affect
Wong, T.J., Dyson, Paul J., Griffioen, A.W., Bonvin, Debora, Griffioen, Arjan W., Weiss, Andrea, Weiss, A., Bonvin, D., Dyson, P.J., Nowak-Sliwinska, P., Scherrer, Edoardo, Wong, Tse J., Berndsen, Robert H., Scherrer, E., Berndsen, R.H., Nowak-Sliwinska, Patrycja   +15 more
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Principles of Modular Tumor Therapy [PDF]

Cancer Microenvironment, 2009
Nature is interwoven with communication and is represented and reproduced through communication acts. The central question is how may multimodal modularly acting and less toxic therapy approaches, defined as modular therapies, induce an objective response or even a continuous complete remission, although single stimulatory or inhibitingly acting drugs ...
Reichle, Albrecht, Hildebrandt, Gerhard C.   +1 more
openaire   +2 more sources

The stemness of hepatocytes is maintained by high levels of lipopolysaccharide via YAP1 activation

Stem Cell Research & Therapy, 2021
Background The liver possesses a powerful regeneration ability, which is correlated with the stemness of hepatocytes in the portal vein (PV). However, the mechanism underlying the maintenance of hepatocyte stemness has not been elucidated.
Changchun Shao, Xue Yang, Yingying Jing, Xiaojuan Hou, Yihua Huang, Chen Zong, Lu Gao, Wenting Liu, Jinghua Jiang, Fei Ye, Junxia Shi, Qiudong Zhao, Rong Li, Xiaoren Zhang, Lixin Wei   +14 more
doaj   +1 more source