Results 241 to 250 of about 3,547,100 (335)

The Road to a Realistic 3D Model for Estimating R₂ and R₂* Relaxation Versus Gd-DTPA Concentration in Whole Blood and Brain Tumor Vasculature. [PDF]

NMR Biomed
van Dorth D, Alafandi A, Soloukey S, Kruizinga P, Venugopal K, Delphin A, Poot DHJ, Christen T, Smits M, de Bresser J, Hernandez-Tamames JA, van Osch MJP.   +11 more
europepmc   +1 more source

AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.

Cancer Cell, 2007
T. Batchelor, A. Sorensen, E. di Tomaso, Wei-Ting Zhang, D. Duda, K. Cohen, Kevin Kozak, D. Cahill, P. Chen, M. Zhu, M. Ancukiewicz, M. Mrugala, S. Plotkin, J. Drappatz, D. Louis, P. Ivy, D. Scadden, T. Benner, J. Loeffler, P. Wen, R. Jain   +20 more
semanticscholar   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies. [PDF]

Sci Transl Med
Lu Z, Verginadis I, Kumazoe M, Castillo GM, Yao Y, Guerra RE, Bicher S, You M, McClung G, Qiu R, Xiao Z, Miao Z, George SS, Beiting DP, Nojiri T, Tanaka Y, Fujimura Y, Onda H, Hatakeyama Y, Nishimoto-Ashfield A, Bykova K, Guo W, Fan Y, Buynov NM, Diehl JA, Stanger BZ, Tachibana H, Gade TP, Puré E, Koumenis C, Bolotin EM, Fuchs SY.   +31 more
europepmc   +1 more source

Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction

Advanced Science, EarlyView.
We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang, Kai Dai, Tong Shen, Zehua Gao, Fengying Yan, Yuke Feng, Xuanlin Wang, Shaozhen Zhang, Jing Wang, Changsheng Liu   +9 more
wiley   +1 more source

Matrix stiffening promotes a tumor vasculature phenotype

Proceedings of the National Academy of Sciences of the United States of America, 2016
François Bordeleau, Brooke N. Mason, E. M. Lollis, M. Mazzola, Matthew R. Zanotelli, Sahana Somasegar, Joseph P. Califano, Christine R. Montague, Danielle J. LaValley, J. Huynh, N. Mencia-Trinchant, Yashira L Negrón Abril, D. Hassane, L. Bonassar, J. Butcher, R. Weiss, Cynthia A. Reinhart-King   +16 more
semanticscholar   +1 more source

Detachment‐Induced FAK‐STAT3‐NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation

Advanced Science, EarlyView.
The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong, Yilei Ma, Yuzhen Gao, Lin Zhou, Luping Lou, Qiang Fang, Sining Fang, Ru Zhao, Jin Zeng, Jun Yang, Guoli Li, Xinyou Xie, Yanzhong Wang, Jun Zhang   +13 more
wiley   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Nucleolin Targeting Impairs the Progression of Pancreatic Cancer and Promotes the Normalization of Tumor Vasculature.

Cancer Research, 2016
Maud-Emmanuelle Gilles, F. Maione, M. Cossutta, G. Carpentier, Laure Caruana, S. Di Maria, Claire Houppe, Damien Destouches, Ksenya Shchors, C. Prochasson, F. Mongelard, S. Lamba, A. Bardelli, P. Bouvet, A. Couvelard, J. Courty, E. Giraudo, Ilaria Cascone   +17 more
semanticscholar   +1 more source