Results 61 to 70 of about 3,547,100 (335)

L1 in tumor vasculature

Oncotarget, 2016
Angiogenesis is a pre-requisite for the growth and the metastatic dissemination of solid tumors. Therefore, interfering with the angiogenic process has long been proposed as a therapeutic strategy to restrain cancer progression [1]. In this context, drugs that inhibit vascular endothelial growth factor (VEGF) signaling have proven efficacious in ...
openaire   +2 more sources

mTOR Inhibition and the Tumor Vasculature

Current Angiogenesis, 2012
Blocking tumor growth by targeting the tumor vasculature is a promising approach in cancer therapy. Both disrupting tumor vessels as well as normalization of tumor vessel abnormalities have shown anti cancer efficacy. A plethora of agents that act on the tumor vasculature have been developed; however so far few have shown clinical benefits.
Dormond-Meuwly Anne, Dufour Marc, Demartines Nicolas, Dormond Olivier   +3 more
openaire   +2 more sources

Intravitreal and Subconjunctival Melphalan for Retinoblastoma in Transgenic Mice

Journal of Ophthalmology, 2014
Purpose. To measure the chemotherapeutic effects of focal melphalan (intravitreal and subconjunctival) on tumor burden, hypoxia, and vasculature in LHBETATAG murine retinoblastoma model. Methods. LHBETATAG transgenic mice were treated with a single 1 mcg
Nisha V. Shah, D. G. Pham, T. G. Murray, C. Decatur, E. Hernandez, Nikesh N. Shah, M. Cavalcante, S. K. Houston   +7 more
doaj   +1 more source

Revisiting tumor angiogenesis: vessel co-option, vessel remodeling, and cancer cell-derived vasculature formation

Chinese Journal of Cancer, 2016
Tumor growth and metastasis depend on the establishment of tumor vasculature to provide oxygen, nutrients, and other essential factors. The well-known vascular endothelial growth factor (VEGF) signaling is crucial for sprouting angiogenesis as well as ...
Chao-Nan Qian, Min-Han Tan, Jun-Ping Yang, Yun Cao   +3 more
doaj   +1 more source

Emergence of Anti-Cancer Drug Resistance: Exploring the Importance of the Microenvironmental Niche via a Spatial Model

, 2014
Practically, all chemotherapeutic agents lead to drug resistance. Clinically, it is a challenge to determine whether resistance arises prior to, or as a result of, cancer therapy.
A. Lorz, A. Lorz, A. Wu, A.L. Correia, A.O. Pisco, A.S. Silva, B. Baguley, C. Bock, D. Woods, D.W. McMillin, E.S. Nakasone, F.A. Meineke, G. Lambert, H. Zahreddine, H.M. Byrne, I. Bozic, J. Foo, J. Foo, J. Greene, J.J. Cunningham, J.J. Kim, J.J. Lee, K. Cheung-Ong, M. Dean, M. Sawicka, M.M. Hadjiandreou, N.L. Komarova, N.L. Komarova, O. Lavi, O. Lavi, O. Trédan, P. Karran, P.A. Orlando, P.P. Provenzano, S. Rottenberg, S.M. Mumenthaler, T. Brocato, T.L. Jackson   +37 more
core   +1 more source

Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer [PDF]

, 2017
Tumor epithelial cells (TEpCs) and spindle-shaped stromal cells, not associated with the vasculature, of patients with early breast cancer express osteoprotegerin (OPG), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), receptor activator ...
Borzone, Francisco Raúl, Chasseing, Norma Alejandra, Choi, Hosoon, Davies, Kevin Mauro, de Luján Calcagno, María, Feldman, Leonardo, García Rivello, Hernán, Giorello, María Belén, Howard, Scott C., Labovsky, Vivian, Martinez, Leandro Marcelo, Matas, Ayelen, Wernicke, Alejandra   +12 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Single-cell transcriptional profiling of clear cell renal cell carcinoma reveals a tumor-associated endothelial tip cell phenotype

Communications Biology
Clear cell renal cell carcinoma (ccRCC) is the most prevalent form of renal cancer, accounting for over 75% of cases. The asymptomatic nature of the disease contributes to late-stage diagnoses and poor survival. Highly vascularized and immune infiltrated
Justina Zvirblyte, Juozas Nainys, Simonas Juzenas, Karolis Goda, Raimonda Kubiliute, Darius Dasevicius, Marius Kincius, Albertas Ulys, Sonata Jarmalaite, Linas Mazutis   +9 more
doaj   +1 more source

Combining antiangiogenic therapy with adoptive cell immunotherapy exerts better antitumor effects in non-small cell lung cancer models. [PDF]

PLoS ONE, 2013
INTRODUCTION: Cytokine-induced killer cells (CIK cells) are a heterogeneous subset of ex-vivo expanded T lymphocytes which are characterized with a MHC-unrestricted tumor-killing activity and a mixed T-NK phenotype.
Shujing Shi, Rui Wang, Yitian Chen, Haizhu Song, Longbang Chen, Guichun Huang   +5 more
doaj   +1 more source

Engaging the Immune Response to Normalize the Tumor Microenvironment [PDF]

, 2013
Solid tumors exist as heterogeneous populations comprised not only of malignant cells, but various other cell types, including cells that make up the vasculature, that can strongly influence tumorgenicity.
Sabins, Nina, Storkus, Walter
core