Results 41 to 50 of about 1,359,527 (294)

Radiotherapy and chemotherapy change vessel tree geometry and metastatic spread in a small cell lung cancer xenograft mouse tumor model. [PDF]

PLoS ONE, 2017
Tumor vasculature is critical for tumor growth, formation of distant metastases and efficiency of radio- and chemotherapy treatments. However, how the vasculature itself is affected during cancer treatment regarding to the metastatic behavior has not ...
Thorsten Frenzel, Bertin Hoffmann, Rüdiger Schmitz, Anja Bethge, Udo Schumacher, Gero Wedemann   +5 more
doaj   +1 more source

Multiparametric MRI enables for differentiation of different degrees of malignancy in two murine models of breast cancer

Frontiers in Oncology, 2022
ObjectiveThe objective of this study was to non-invasively differentiate the degree of malignancy in two murine breast cancer models based on identification of distinct tissue characteristics in a metastatic and non-metastatic tumor model using a ...
Mirjam Gerwing, Mirjam Gerwing, Emily Hoffmann, Emily Hoffmann, Katharina Kronenberg, Uwe Hansen, Max Masthoff, Max Masthoff, Anne Helfen, Anne Helfen, Christiane Geyer, Christiane Geyer, Lydia Wachsmuth, Lydia Wachsmuth, Carsten Höltke, Carsten Höltke, Bastian Maus, Bastian Maus, Verena Hoerr, Verena Hoerr, Verena Hoerr, Tobias Krähling, Tobias Krähling, Lena Hiddeßen, Walter Heindel, Walter Heindel, Uwe Karst, Melanie A. Kimm, Regina Schinner, Michel Eisenblätter, Michel Eisenblätter, Michel Eisenblätter, Cornelius Faber, Cornelius Faber, Moritz Wildgruber, Moritz Wildgruber, Moritz Wildgruber   +36 more
doaj   +1 more source

Is Sphingosine-1-Phosphate a Regulator of Tumor Vascular Functionality?

, 2022
Increasing evidence indicates that tumor vasculature normalization could be an appropriate strategy to increase therapies’ efficacy in solid tumors by decreasing hypoxia and improving drug delivery.
Annette Ives, Manale Karam, Christian Auclair   +2 more
core   +1 more source

Subsequent Ultrasound Vascular Targeting Therapy of Hepatocellular Carcinoma Improves the Treatment Efficacy

Biology, 2021
The response of hepatocellular carcinoma (HCC) to anti-vascular ultrasound therapy (AVUS) can be affected by the inherent differences in tumor vascular structure, and the functionality of tumor vessels at the time of treatment. In this study, we evaluate
Laith R. Sultan, Mrigendra B. Karmacharya, Stephen J. Hunt, Andrew K.W. Wood, Chandra M. Sehgal   +4 more
doaj   +1 more source

Pericytes on the Tumor Vasculature: Jekyll or Hyde? [PDF]

Cancer Microenvironment, 2012
The induction of tumor vasculature, known as the 'angiogenic switch', is a rate-limiting step in tumor progression. Normal blood vessels are composed of two distinct cell types: endothelial cells which form the channel through which blood flows, and mural cells, the pericytes and smooth muscle cells which serve to support and stabilize the endothelium.
Keith D, Barlow, Anne M, Sanders, Shay, Soker, Suleyman, Ergun, Linda J, Metheny-Barlow   +4 more
openaire   +2 more sources

New molecular mediators in tumor angiogenesis [PDF]

, 2007
Angiogenesis is essential for tumor growth and progression. It has been demonstrated that tumor growth beyond a size 1 to 2 mm3 requires the induction of new vessels.
Jonas, Dietger, Beecken, Wolf-Dietrich, Kramer, Wolfgang   +2 more
core   +1 more source

Combining antiangiogenic therapy with adoptive cell immunotherapy exerts better antitumor effects in non-small cell lung cancer models. [PDF]

PLoS ONE, 2013
INTRODUCTION: Cytokine-induced killer cells (CIK cells) are a heterogeneous subset of ex-vivo expanded T lymphocytes which are characterized with a MHC-unrestricted tumor-killing activity and a mixed T-NK phenotype.
Shujing Shi, Rui Wang, Yitian Chen, Haizhu Song, Longbang Chen, Guichun Huang   +5 more
doaj   +1 more source

Quantitative Immunohistochemistry for Evaluating the Distribution of Ki67 and Other Biomarkers in Tumor Sections and Use of the Method to Study Repopulation in Xenografts after Treatment with Paclitaxel

Neoplasia: An International Journal for Oncology Research, 2012
Background: Surviving cells may repopulate tumors between courses of chemotherapy, thereby reducing the effectiveness of treatment. Using a novel quantitative method, we characterize the influence of the tumor microenvironment on repopulation of ...
Andrea S. Fung, James Jonkman, Ian F. Tannock   +2 more
doaj   +1 more source

L1 in tumor vasculature

Oncotarget, 2016
Angiogenesis is a pre-requisite for the growth and the metastatic dissemination of solid tumors. Therefore, interfering with the angiogenic process has long been proposed as a therapeutic strategy to restrain cancer progression [1]. In this context, drugs that inhibit vascular endothelial growth factor (VEGF) signaling have proven efficacious in ...
openaire   +2 more sources

Untangling Tumor Vasculature

The FASEB Journal, 2013
Tumor vasculature is highly dynamic, dense, and non‐homogeneous. These features make it difficult to identify key determinants of tumor angiogenesis and remodeling at the single vessel level. To overcome this problem, we isolated growing tumors from the host tissue, by placing a perforated PDMS disk between the tumor and the dorsal skin in transparent ...
Gabriel Gruionu, Despina Bazou, Johnatan Song   +2 more
openaire   +1 more source