Tumor-Vasculature-on-a-Chip for Investigating Nanoparticle Extravasation and Tumor Accumulation
, 2018 Nanoparticle tumor accumulation relies on a key mechanism, the enhanced permeability and retention (EPR) effect, but it remains challenging to decipher the exact impact of the EPR effect.
David A. Weitz (266457) +15 more
core +2 more sources
Antiangiogenic therapy reverses the immunosuppressive breast cancer microenvironment
Biomarker Research, 2021 Tumor angiogenesis induces local hypoxia and recruits immunosuppressive cells, whereas hypoxia subsequently promotes tumor angiogenesis. Immunotherapy efficacy depends on the accumulation and activity of tumor-infiltrating immune cells (TIICs ...
Wuzhen Chen +7 more
doaj +1 more source
Endothelial cell-specific LAT1 ablation normalizes tumor vasculature. [PDF]
JCI InsightSome endothelial cells in the tumor vasculature express a system L amino acid transporter, LAT1. To elucidate the role of LAT1 in tumor-related endothelial cells, tumor cells were injected into endothelial cell–specific LAT1 conditional knockout mice ...
Suehiro JI +8 more
europepmc +2 more sources
Numerical simulation of solid tumor blood perfusion and drug delivery during the “vascular normalization window” with antiangiogenic therapy [PDF]
, 2011 This Article is provided by the Brunel Open Access Publishing Fund - Copyright @ 2011 Hindawi PublishingTo investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network ...
Long, Q +13 more
core +1 more source
Tumor metastasis and the lymphatic vasculature
International Journal of Cancer, 2009 AbstractTumor‐associated lymphatic vessels act as a conduit by which disseminating tumor cells access regional lymph nodes and form metastases there. Lymph node metastasis is of major prognostic significance for many types of cancer, although lymph node metastases are themselves rarely life‐threatening.
Sleeman, J. P., Thiele, W.
openaire +3 more sources
Tumor-induced myeloid cell plasticity toward lymphatic endothelium [PDF]
, 2009 Tumor-associated lymphangiogenesis contributes to tumor progression by regulating interstitial fluid pressure, transporting immune cells to the tumor site and providing a route for metastatic dissemination.
Baeriswyl, Vanessa
core +1 more source
The Pleiotropic Role of L1CAM in Tumor Vasculature [PDF]
International Journal of Molecular Sciences, 2017 Angiogenesis, the formation of new vessels, is a key step in the development, invasion, and dissemination of solid tumors and, therefore, represents a viable target in the context of antitumor therapy. Indeed, antiangiogenic approaches have given promising results in preclinical models and entered the clinical practice.
Francesca Angiolini, Ugo Cavallaro
openaire +2 more sources
Krüppel-like factor 8 (KLF8) is expressed in gliomas of different WHO grades and is essential for tumor cell proliferation. [PDF]
, 2012 Krüppel-like factor 8 (KLF8) has only recently been identified to be involved in tumor cell proliferation and invasion of several different tumor entities like renal cell carcinoma, hepatocellular carcinoma and breast cancer.
Schnell, Oliver +44 more
core +2 more sources
Nanoparticle Delivery and Tumor Vascular Normalization: The Chicken or The Egg?
Frontiers in Oncology, 2019 Tumor-induced angiogenesis has been a significant focus of anti-cancer therapies for several decades. The immature and “leaky” tumor vasculature leads to significant cancer cell intravasation, increasing the metastatic potential, while the disoriented ...
George Mattheolabakis +1 more
doaj +1 more source
Interactions Between Anti-Angiogenic Therapy and Immunotherapy in Glioblastoma
Frontiers in Oncology, 2022 Glioblastoma is the most aggressive brain tumor with a median survival ranging from 6.2 to 16.7 months. The complex interactions between the tumor and the cells of tumor microenvironment leads to tumor evolution which ultimately results in treatment ...
Saket Jain +2 more
doaj +1 more source