Results 51 to 60 of about 1,359,527 (294)

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]

, 2012
Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Devraj, Kavi, Nicole Ziegler, Fruttiger, Marcus, Rosario Heck, Sascha Seidel, Sonja Thom, Taketo, Makoto Mark, Kavi Devraj, Seidel, Sascha, Karl H. Plate, Liebner, Stefan, Reis, Marco, Bockamp, Ernesto, Heck, Rosario, Ernesto Bockamp, Marco Reis, Cathrin J. Czupalla, Makoto M. Taketo, Thom, Sonja, Zinke, Jenny, Plate, Karl, Macas, Jadranka, Jenny Zinke, Czupalla, Cathrin Jacqueline, Jadranka Macas, Stefan Liebner, Stefanie Dimmeler, Dimmeler, Stefanie, Ziegler, Nicole, Marcus Fruttiger   +29 more
core   +1 more source

Metabolites and Immune Response in Tumor Microenvironments

, 2023
The remodeled cancer cell metabolism affects the tumor microenvironment and promotes an immunosuppressive state by changing the levels of macro- and micronutrients and by releasing hormones and cytokines that recruit immunosuppressive immune cells. Novel
Salvatore Cortellino, Valter D. Longo
core   +1 more source

A Facile Method to Probe the Vascular Permeability of Nanoparticles in Nanomedicine Applications

Scientific Reports, 2017
The effectiveness of nanoparticles (NP) in nanomedicine depends on their ability to extravasate from vasculature towards the target tissue. This is determined by their permeability across the endothelial barrier.
Yan Teck Ho, Giulia Adriani, Sebastian Beyer, Phan-Thien Nhan, Roger D. Kamm, James Chen Yong Kah   +5 more
doaj   +1 more source

Revisiting tumor angiogenesis: vessel co-option, vessel remodeling, and cancer cell-derived vasculature formation

Chinese Journal of Cancer, 2016
Tumor growth and metastasis depend on the establishment of tumor vasculature to provide oxygen, nutrients, and other essential factors. The well-known vascular endothelial growth factor (VEGF) signaling is crucial for sprouting angiogenesis as well as ...
Chao-Nan Qian, Min-Han Tan, Jun-Ping Yang, Yun Cao   +3 more
doaj   +1 more source

Normalization of tumor vasculature by R-Ras [PDF]

Cell Cycle, 2012
Malfunction of blood vessels and abnormal vessel growth are associated with various medical conditions ranging from heart disease, cancer and metabolic problems, such as diabetes, to age-related co...
Sawada, Junko, Komatsu, Masanobu
openaire   +2 more sources

MRI and US imaging reveal evolution of spatial heterogeneity of murine tumor vasculature [PDF]

, 2022
The tumor microenvironment, especially the vasculature, undergoes dynamic remodeling during tumor growth and progression. The aim of this study was to investigate changes in the structure and function of tumor microenvironment (TME), with a special focus
Martyna Elas, Drzał, Agnieszka, Agnieszka Drzał, Michał Gonet, Krzysztof Jasiński, Ewa Kowolik, Elas, Martyna, Bartel, Żaneta, Kowolik, Ewa, Jasiński, Krzysztof, Żaneta Bartel, Gonet, Michał   +11 more
core   +1 more source

Intravitreal and Subconjunctival Melphalan for Retinoblastoma in Transgenic Mice

Journal of Ophthalmology, 2014
Purpose. To measure the chemotherapeutic effects of focal melphalan (intravitreal and subconjunctival) on tumor burden, hypoxia, and vasculature in LHBETATAG murine retinoblastoma model. Methods. LHBETATAG transgenic mice were treated with a single 1 mcg
Nisha V. Shah, D. G. Pham, T. G. Murray, C. Decatur, E. Hernandez, Nikesh N. Shah, M. Cavalcante, S. K. Houston   +7 more
doaj   +1 more source

A review of the development of tumor vasculature and its effects on the tumor microenvironment [PDF]

, 2017
Background: The imbalance of angiogenic regulators in tumors drives tumor angiogenesis and causes the vasculature to develop much differently in tumors than in normal tissue.
Michael Douglass, Forster, J.C., Eva Bezak, Jake Forster, Harriss-Phillips, W.M., Wendy Harriss-Phillips, Douglass, M.J., Bezak, E.   +7 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Single-cell transcriptional profiling of clear cell renal cell carcinoma reveals a tumor-associated endothelial tip cell phenotype

Communications Biology
Clear cell renal cell carcinoma (ccRCC) is the most prevalent form of renal cancer, accounting for over 75% of cases. The asymptomatic nature of the disease contributes to late-stage diagnoses and poor survival. Highly vascularized and immune infiltrated
Justina Zvirblyte, Juozas Nainys, Simonas Juzenas, Karolis Goda, Raimonda Kubiliute, Darius Dasevicius, Marius Kincius, Albertas Ulys, Sonata Jarmalaite, Linas Mazutis   +9 more
doaj   +1 more source