Results 21 to 30 of about 1,359,527 (294)
Cell Reports, 2023 Summary: CD8+ T cell recruitment to the tumor microenvironment is critical for the success of adoptive cell therapy (ACT). Unfortunately, only a small fraction of transferred cells home to solid tumors.
Camila P. Camargo +8 more
doaj +1 more source
Dysembryoplastic Neuroepithelial Tumor: A Benign but Complex Tumor of the Cerebral Cortex [PDF]
, 2022 Dysembryoplastic neuroepithelial tumor (DNET) is a distinct type of low-grade glioneuronal tumor. Clinically, DNET is highly associated with intractable epilepsy in young children and adolescents.
김세훈
core +1 more source
Platelets: Guardians of Tumor Vasculature [PDF]
Cancer Research, 2009 Abstract Solid tumors generate a prothrombotic environment capable of platelet activation. Recent findings indicate that the activated platelets are crucial regulators of tumor vascular homeostasis in that they prevent tumor hemorrhage. Surprisingly, this effect is independent of platelets' capacity to form thrombi and instead relies on ...
Benoit, Ho-Tin-Noé +2 more
openaire +2 more sources
Engineering tumoral vascular leakiness with gold nanoparticles
Nature Communications, 2023 Delivering cancer therapeutics to tumors necessitates their escape from the surrounding blood vessels. Tumor vasculatures are not always sufficiently leaky. Herein, we engineer therapeutically competent leakage of therapeutics from tumor vasculature with
Magdiel Inggrid Setyawati +8 more
doaj +1 more source
Research Progress of Radiolabeled Asn-Gly-Arg (NGR) Peptides for Imaging and Therapy
Molecular Imaging, 2020 Asn-Gly-Arg (NGR) motifs have vasculature-homing properties via interactions with the aminopeptidase N (CD13) expressed on tumor neovasculature. Numerous NGR peptides with different molecular scaffolds have been exploited for targeted delivery of ...
Liqin Zhu MD +4 more
doaj +1 more source
Quantifying the effects of antiangiogenic and chemotherapy drug combinations on drug delivery and treatment efficacy. [PDF]
PLoS Computational Biology, 2017 Tumor-induced angiogenesis leads to the development of leaky tumor vessels devoid of structural and morphological integrity. Due to angiogenesis, elevated interstitial fluid pressure (IFP) and low blood perfusion emerge as common properties of the tumor ...
Sirin Yonucu +4 more
doaj +1 more source
BMC Genomics, 2008 Background Targeting tumor angiogenesis and vasculature is a promising strategy for the inhibition of tumor growth and dissemination. Evidence suggests that tumor vasculature expresses unique markers that distinguish it from normal vasculature.
Giavazzi Raffaella +5 more
doaj +1 more source
Tumor spheroid-based and microtumor-based vascularized models for replicating the vascularized tumor microenvironment [PDF]
Organoid, 2023 Background Tumor vasculature is a crucial pathway for supplying nutrients and oxygen to tumors during their progression, as well as facilitating the delivery of anticancer drugs or immunotherapeutic agents.
Jiyoung Song +4 more
doaj +1 more source
A Role for All-Trans-Retinoic Acid in the Early Steps of Lymphatic Vasculature Development [PDF]
, 2010 The molecular mechanisms that regulate the earliest steps of lymphatic vascular system development are unknown. To identify regulators of lymphatic competence and commitment, we used an in vitro vascular assay with mouse embryonic stem cell-derived ...
Dabouras, Vasilios +7 more
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iScience, 2023 Summary: Tumor vasculature often exhibits disorder and inefficiency. Vascular normalization offers potential for alleviating hypoxia and optimizing drug delivery in tumors.
Jian Zhong +14 more
doaj +1 more source