Results 1 to 10 of about 133,228 (112)

Immunotherapies targeting tumor vasculature: challenges and opportunities [PDF]

Frontiers in Immunology, 2023
Angiogenesis is a hallmark of cancer biology, and neoadjuvant therapies targeting either tumor vasculature or VEGF signaling have been developed to treat solid malignant tumors.
Hassan Dianat-Moghadam, Hassan Dianat-Moghadam, Reza Nedaeinia, Mohsen Keshavarz, Mehdi Azizi, Mohammad Kazemi, Rasoul Salehi, Rasoul Salehi   +7 more
doaj   +2 more sources

GPU-accelerated volumetric-mosaic optical-resolution photoacoustic microscopy and quantifying tumor vasculature growth [PDF]

Photoacoustics
Tumor growth is closely linked to vascular remodeling, yet comprehensive volumetric imaging of tumor vasculature using photoacoustic microscopy (PAM) remains challenging due to limitations in the field of view, depth penetration, and processing speed ...
Thanh Dat Le, Thi Thao Mai, Qiwei Lin, Xingshu Li, Jung-Joon Min, Changho Lee   +5 more
doaj   +2 more sources

Human Patient-Derived Brain Tumor Models to Recapitulate Ependymoma Tumor Vasculature [PDF]

Bioengineering, 2023
Despite in vivo malignancy, ependymoma lacks cell culture models, thus limiting therapy development. Here, we used a tunable three-dimensional (3D) culture system to approximate the ependymoma microenvironment for recapitulating a patient’s tumor in ...
Min D. Tang-Schomer, Markus J. Bookland, Jack E. Sargent, Taylor N. Jackvony   +3 more
doaj   +2 more sources

Aberrant tumor vasculature. Facts and pitfalls [PDF]

Frontiers in Pharmacology
Endothelial cells form a single cell layer lining the inner walls of blood vessels and play critical roles in organ homeostasis and disease progression.
Domenico Ribatti
doaj   +2 more sources

JP1 normalizes tumor vasculature to suppress metastasis and facilitate drug delivery by inhibiting IL-8 [PDF]

JCI Insight, 2023
Tumor vascular normalization prevents tumor cells from breaking through the basement membrane and entering the vasculature, thereby inhibiting metastasis initiation.
Jiahua Cui, Zhen Che, Lu Zou, Dongyin Chen, Zhan Xie, Kun Ding, Huning Jiang, Aiping Li, Jianwei Zhou, Yongqian Shu   +9 more
doaj   +2 more sources

Gold nanoparticle-enhanced radiotherapy: Dependence of the macroscopic dose enhancement on the microscopic localization of the nanoparticles within the tumor vasculature. [PDF]

PLoS ONE
In gold nanoparticle-enhanced radiotherapy, intravenously administered nanoparticles tend to accumulate in the tumor tissue by means of the so-called permeability and retention effect and upon irradiation with x-rays, the nanoparticles release a ...
C A Díaz-Galindo, H M Garnica-Garza
doaj   +2 more sources

Tumor Vasculature as an Emerging Pharmacological Target to Promote Anti-Tumor Immunity [PDF]

International Journal of Molecular Sciences, 2023
Hong-Tai Tzeng
exaly   +2 more sources

Non-immune functions of B7-H3: bridging tumor cells and the tumor vasculature [PDF]

Frontiers in Oncology
Shuo Wu, Kaiyuan Hui
exaly   +2 more sources

Angiogenesis modulated by CD93 and its natural ligands IGFBP7 and MMRN2: a new target to facilitate solid tumor therapy by vasculature normalization

Cancer Cell International, 2023
The tumor vasculature was different from the normal vasculature in both function and morphology, which caused hypoxia in the tumor microenvironment (TME). Previous anti-angiogenesis therapy had led to a modest improvement in cancer immunotherapy. However,
Yang Li, Lei Fu, Baokang Wu, Xingqi Guo, Yu Shi, Chao Lv, Yang Yu, Yizhou Zhang, Zhiyun Liang, Chongli Zhong, Shukun Han, Feng Xu, Yu Tian   +12 more
doaj   +1 more source

Heterogeneity of tumor vasculature and antiangiogenic intervention: insights from MR angiography and DCE-MRI. [PDF]

PLoS ONE, 2014
Solid tumor vasculature is highly heterogeneous, which presents challenges to antiangiogenic intervention as well as the evaluation of its therapeutic efficacy.
Wenlian Zhu, Yoshinori Kato, Dmitri Artemov   +2 more
doaj   +1 more source