Results 11 to 20 of about 1,359,527 (294)
Nucleic Acid Sensing in the Tumor Vasculature. [PDF]
Cancers (Basel), 2021 Endothelial cells form a powerful interface between tissues and immune cells. In fact, one of the underappreciated roles of endothelial cells is to orchestrate immune attention to specific sites. Tumor endothelial cells have a unique ability to dampen the immune responses and thereby maintain an immunosuppressive microenvironment.
Baris AM, Fraile-Bethencourt E, Anand S.
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Targeting tumor vasculature [PDF]
, 2009 Targeting tumor vasculature is the common theme for the three separate studies presented in this thesis. The studies comprise the roles of components of three signaling pathways (networks) in several steps of blood vessel formation, and related tumor growth and dissemination.
Samaržija, Ivana
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mTOR Inhibition and the Tumor Vasculature
Current Angiogenesis, 2012 Blocking tumor growth by targeting the tumor vasculature is a promising approach in cancer therapy. Both disrupting tumor vessels as well as normalization of tumor vessel abnormalities have shown anti cancer efficacy. A plethora of agents that act on the tumor vasculature have been developed; however so far few have shown clinical benefits.
Dormond-Meuwly Anne +3 more
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Effects of radiation on tumor vasculature
Molecular Carcinogenesis, 2021 AbstractRadiation has been utilized as a direct cytotoxic tumorcidal modality, however, the effect of radiation on tumor vasculature influences response to anticancer therapies. Although numerous reports have demonstrated vascular changes in irradiated tumors, the findings and implications are extensive and at times contradictory depending on the ...
Tomoko Yamazaki, Kristina H. Young
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Smart Nanotherapeutic Targeting of Tumor Vasculature
Accounts of Chemical Research, 2019 The past decades have witnessed the development of a field dedicated to targeting tumor vasculature for cancer therapy. In contrast to conventional chemotherapeutics that need to penetrate into tumor tissues for killing tumor cells, the agents targeting tumor vascular system have two major advantages: direct contact with vascular endothelial cells or ...
Zifu Li +4 more
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Tumor vasculature: a sally port for inhibiting cancer cell spreading
Cancer Communications, 2018 The close relationship between metastasis and establishment of tumor vasculature has inspired enormous research interests aiming to suppress metastasis via inhibiting the development of tumor vasculature.
Chao-Nan Qian, Francesco Pezzella
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Magnetic resonance imaging of tumor vasculature
Thrombosis and Haemostasis, 2003 SummaryAngiogenic activity and formation of a vascular network facilitate tumor perfusion and play a critical role in tumor growth and metastasis. Tumor vasculature may be visualized by means of parametric imaging of specific morphological and physiological characteristics that collectively describe its properties.
Hadassa, Degani +3 more
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Targeting autophagy in dysfunctional tumor vasculature. [PDF]
iScienceTumor vasculature drives cancer progression and therapeutic resistance, with autophagy serving as a critical regulator of endothelial cell function. This review synthesizes current knowledge of autophagy in tumor vasculature, examining molecular mechanisms, cellular interactions, and therapeutic applications.
Lin Q +8 more
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Heterogeneity of the Tumor Vasculature [PDF]
Seminars in Thrombosis and Hemostasis, 2010 The blood vessels supplying tumors are strikingly heterogeneous and differ from their normal counterparts with respect to organization, structure, and function. Six distinctly different tumor vessel types have been identified, and much has been learned about the steps and mechanisms by which they form.
Janice A, Nagy +4 more
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Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors
Nature Communications, 2023 Targeting DNA methyltransferase 1 (DNMT1) has immunomodulatory and anti-neoplastic activity, especially when paired with cancer immunotherapies. Here we explore the immunoregulatory functions of DNMT1 in the tumor vasculature of female mice.
Dae Joong Kim +11 more
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