Results 251 to 260 of about 3,141,404 (351)

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Syncytium-forming HSV-1 in cancer gene therapy: From molecular mechanisms to clinical translation. [PDF]

Virulence
Zhao X, Zhang H, Xu S, Mei L, Feng Z, Wang D, Huang W, Shen Y.   +7 more
europepmc   +1 more source

Nicotinamide Metabolism Constrains Memory CD8+ T Cell Formation Through a Putative HS1BP3‐SIRT1‐FOXO3‐BCL6 Axis

Advanced Science, EarlyView.
ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Siyang Wang, Xiaoqian Fan, Yifan Huang, Chang Yao, Jixing Fan, Yu Ping, Xuan Zhao, Congcong Li, Chunyi Shen, Jiqi Shan, Jinyan Liu, Shengdian Wang, Zhen Zhang, Yi Zhang   +13 more
wiley   +1 more source

Hypoxia increases the activity of oncolytic adenoviruses through HIF-2α-stimulated E1A expression. [PDF]

Signal Transduct Target Ther
Jacobus EJ, Lafleur VN, Fisher KD, Mole DR, Seymour LW.   +4 more
europepmc   +1 more source

A case of disseminated and acyclovir-resistant tumoral herpes simplex virus 2 infection in an immunocompromised patient

Taylor J. Prechtel, Ginat W. Mirowski, Brandon A. Umphress, Brad E. Rumancik, Honglin Xiao, Rachel P. Kowal   +5 more
openalex   +1 more source

Translational Barriers and AI‐Driven Challenges of Microfluidics‐Enabled Wearables and Implantable Systems in Personalized Medicine

Advanced Science, EarlyView.
An integrative review of microfluidics‐enabled wearables and implantable systems reveals a single‐track translation pipeline, bridging functional biomaterials with clinical utility. Dynamic feedback loops driven by artificial intelligence advance diagnostics toward personalized closed‐loop theranostics.
Ke Huang, Ching Yin Fong, Xin Huang, Bee Luan Khoo   +3 more
wiley   +1 more source

Progressive Human Orf Virus Infection in a Kidney Transplant Recipient Successfully Treated with Cryotherapy Without Modification of Immunosuppression: A Case Report. [PDF]

Int J Nephrol Renovasc Dis
Rahmoon SM, AbuAfifeh LM, Alkhalidi OA, Ahmad F, Alfitori GBS.   +4 more
europepmc   +1 more source

Effect of Epstein-Barr Virus Infection on the Treatment of Gastric Cancer in Tumor Immunotherapy

Tiancheng Xu
openalex   +2 more sources

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source

Special Issue: "Molecular Insights into Zoonotic Diseases". [PDF]

Int J Mol Sci
Venketaraman V.
europepmc   +1 more source