Results 91 to 100 of about 97,107 (209)

The Role of Mesenchymal Reprogramming in Malignant Clonal Evolution and Intra-Tumoral Heterogeneity in Glioblastoma

Cells
Glioblastoma (GBM) is the most common yet uniformly fatal adult brain cancer. Intra-tumoral molecular and cellular heterogeneities are major contributory factors to therapeutic refractoriness and futility in GBM.
Qiong Wu, Anders E. Berglund, Robert J. Macaulay, Arnold B. Etame   +3 more
doaj   +1 more source

THE A3 ADENOSINE RECEPTOR: A LINK BETWEEN INFLAMMATION AND CANCER.

, 2010
Adenosine is an endogenous and ubiquitous nucleoside that exerts many biological functions through interaction with 4 distinct subtypes of G protein-coupled receptors divided into A1, A2A, A2B, and A3.
Sacchetto, Valeria
core  

PD-L1 assessment in lung cancer biopsies—pitfalls and limitations

The International Journal of Biological Markers
The programmed cell death-ligand 1 (PD-L1) protein expression on tumor cells predicts the efficacy of immunotherapy in patients with non-small cell lung cancer.
Daniela Gompelmann, Pavla Sarova, Berta Mosleh, Anastasia Papaporfyriou, Felicitas Oberndorfer, Marco Idzko, Mir Alireza Hoda   +6 more
doaj   +1 more source

Efeito dos glicosaminoglicanos (GAGs) sobre a progressão do glioma C6: abordagens in vitro e in vivo / [PDF]

, 2001
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas.O presente estudo tem por objetivo verificar efeitos dos glicosaminoglicanos sobre a adesão in vitro do glioma C6.
Soares, Bruno Lobão
core  

A Novel Mechanism Regulating Dopamine Receptor Type 2 Signal Transduction in Pituitary Tumoral Cells: The Role of cAMP/PKA-Induced Filamin A Phosphorylation. [PDF]

Front Endocrinol (Lausanne), 2020
Mangili F, Treppiedi D, Catalano R, Marra G, Di Muro G, Spada A, Arosio M, Peverelli E, Mantovani G.   +8 more
europepmc   +1 more source

Development and In Vitro Cytotoxicity Evaluation of Individual and Combined Injectable Solutions of Curcumin and Resveratrol Against Lung Cancer Cells

Antioxidants
The objective of the present study was to develop injectable solutions of curcumin (CUR) and resveratrol (RES) for intravenous administration as a strategy to increase their solubility and stability, as well as to evaluate their cytotoxic potential ...
Ximena Hernández Martínez, Carla O. Contreras-Ochoa, Marisol Mir-Garcia, Nataly Aguilar-García, Hugo Cortés Martínez, Elvia A. Morales-Hipólito, Sandra L. Hernández-Ojeda, Mariana Dolores-Hernández, Bruno Solis-Cruz, J. J. Espinosa-Aguirre, Daniel Hernandez-Patlan, Raquel López-Arellano   +11 more
doaj   +1 more source

DIFFERENTIAL INFLUENCE OF HYPOXIA ON GENE EXPRESSION OF TUMORAL AND NON TUMORAL MAMMARY CELLS

, 2015
Cancer metastasis is the result of a series of deregulated biological phenomena, including alterations of cell-cell and cell-matrix interactions and of other microenvironmental conditions such as the oxygen tissue supply.
DI CARA, G, MUSSO, R, CANCEMI, Patrizia, FILIPPI, I, CARRARO, F, PUCCI MINAFRA, I., ALBANESE, Nadia Ninfa   +6 more
core  

Crosstalk between normal and tumoral brain cells. Effect on sex steroid metabolism

, 1998
The present article shows for the first time that two cell lines derived respectively from a rat glioma (C6 cell line) and from a human astrocytoma (1321N1 cell line) are able to convert testosterone and progesterone into their corresponding 5 alpha ...
V. Magnaghi, L. Martini, M. Motta, M. Ballabio, I. Cavarretta, R.C. Melcangi   +5 more
core   +1 more source

Addressing intra-tumoral heterogeneity and therapy resistance.

, 2016
In the last several years, our appreciation of intra-tumoral heterogeneity has greatly increased due to accumulating evidence for the co-existence of genetically and epigenetically divergent cancer cells residing in different microenvironments within a ...
Yun, Kyuson, Rybinski, Brad
core   +1 more source

023 | Chaperone-associated macrophage polarization and extracellular matrix remodelling in human glioblastoma

Journal of Biological Research
Glioblastoma (GBM) is the most aggressive central nervous system tumor, with a poor prognosis and no effective treatment because of its high invasiveness, metabolic rate, and heterogeneity.
Società Italiana di Biologia Sperimentale
doaj