Results 211 to 220 of about 527,270 (344)

Correction: SF3B4 downregulation restrains lung adenocarcinoma tumorigenesis via 5' alternative splicing of KAT2A. [PDF]

Sci Rep
Qu A, Han B, Hua M, Wang C, Li T.
europepmc   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

The moonlighting functions of glycolytic enzymes in tumorigenesis. [PDF]

Cell Oncol (Dordr)
Chen X, Yang J, Ma Y.
europepmc   +1 more source

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

, 2014
Hayley L. Belnoue-Davis, Shazia Irshad, Mukesh Bansal, Hannah Rafferty, Tatjana Boitsova, Chiara Bardella, Emma Jaeger, Annabelle Lewis, Luke Freeman-Mills, Francesc Castro-Giner, Pedro Rodenas-Cuadrado, Sreelakshmi Mallappa, Susan K. Clark, Huw Thomas, Rosemary Jeffery, Richard Poulsom, Manuel Rodriguez‐Justo, Marco Novelli, Runjan Chetty, Andrew Silver, Owen J. Sansom, Florian R. Greten, Lai Mun Wang, James E. East, Ian Tomlinson, Simon J. Leedham   +25 more
openalex   +1 more source

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

FTO-mediated m6A demethylation of CSF3 suppresses NETosis via downregulation of RLN2 expression in colorectal cancer. [PDF]

Cell Biol Toxicol
Xu J, Zhang J, Li R, Chen S, Duan C, Ma X, Wang X, Liu X, Gu L, Meng K, Li M.   +10 more
europepmc   +1 more source

Ovarian Tumorigenesis [PDF]

The American Journal of Pathology, 2004
Ie-Ming Shih, Robert J. Kurman
openaire   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets. [PDF]

MedComm (2020)
Liu X, Wang Z, Zhu H, Han Y, Ji Q.
europepmc   +1 more source

Reversible tumorigenesis [PDF]

Cancer Biology & Therapy, 2004
openaire   +1 more source