Results 41 to 50 of about 155,806 (387)

Evidence of calcium-activated potassium channel subunit alpha-1 as a key promoter of glioma growth and tumorigenicity

Glioma, 2019
Background and Aim: Mechanisms of glioma progression are poorly understood. Upregulation of calcium-activated potassium channel subunit alpha-1 (KCNMA1), which encodes the α-subunit of maxi-calcium-activated potassium (BKCa) channels, is shown to be a ...
Divya Khaitan, Nagendra Ningaraj
doaj   +1 more source

Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance As carcinoma cells progress toward high-grade malignancy, they often if not invariably activate the cell-biological program termed the epithelial–mesenchymal transition (EMT).
Cornelia Kröger, Alexander Afeyan, J. Mraz, E. Eaton, Ferenc Reinhardt, Y. Khodor, P. Thiru, Brian Bierie, X. Ye, C. Burge, R. Weinberg   +10 more
semanticscholar   +1 more source

Clinical Implication of Targeting of Cancer Stem Cells [PDF]

, 2012
The existence of cancer stem cells (CSCs) is receiving increasing interest particularly due to its potential ability to enter clinical routine. Rapid advances in the CSC field have provided evidence for the development of more reliable anticancer ...
Al-Hajj M, Bao S, Bardsley MR, Barlogie B, Bentzen SM, Bertout JA, Blazek ER, Bruns CJ, Brunsvig PF, C.J. Bruns, Cao X, Chen MS, Clayton S, Collins AT, Cortes J, Costello R, Dalerba P, Diehn M, Dou J, Dylla SJ, Eyler CE, Fischer S, Garvalov BK, Ghiaur G, Gibbs CP, Gilbert CA, H. Niess, Haferlach T, Hochhaus A, Hosen N, Huff CA, Hurwitz H, Jiang X, Jones RJ, Jones RJ, Jones RJ, Ju Z, K.-W. Jauch, Kanamori M, Kiladjian JJ, Klonisch T, Kojima T, Korpal M, L. Zhao, Li C, Liu G, Liu R, Liu S, Lonardo E, Mauro MJ, McDermott SP, Merante S, Mimeault M, Moserle L, O’Brien SG, Park CY, Phillips TM, Platet N, Q. Bao, Rasheed ZA, Reya T, Reya T, Richardson GD, Roeder I, Seidel S, Singh A, Singh SK, Strojnik T, Stupp R, Suh MR, Szotek PP, Tang C, Tang M, Todaro M, Tu LC, Vermeulen L, Wilson BJ, Wright MH, Xu N, Y. Zhao, Yu F, Zhao C, Zhou BB   +82 more
core   +1 more source

Differentiation-Defective Human Induced Pluripotent Stem Cells Reveal Strengths and Limitations of the Teratoma Assay and In Vitro Pluripotency Assays

Stem Cell Reports, 2017
The ability to form teratomas in vivo containing multiple somatic cell types is regarded as functional evidence of pluripotency for human pluripotent stem cells (hPSCs).
Marga J. Bouma, Maarten van Iterson, Bart Janssen, Christine L. Mummery, Daniela C.F. Salvatori, Christian Freund   +5 more
doaj   +1 more source

Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population [PDF]

, 2016
The identification of signaling pathways that affect the cancer stem-like phenotype may provide insights into therapeutic targets for combating embryonal rhabdomyosarcoma.
Ciccarelli, Carmela, DI PAOLO, Virginia, Giampaolo, Adele, Gravina, GIOVANNI LUCA, Hassan, Hamisa Jane, Macioce, Giampiero, Marampon, Francesco, Milazzo, Luisa, Tombolini, Vincenzo, Vulcano, Francesca, Zani, Bianca Maria   +10 more
core   +9 more sources

Rapamycin Response in Tumorigenic and Non-Tumorigenic Hepatic Cell Lines

PLoS ONE, 2009
The mTOR inhibitor rapamycin has anti-tumor activity across a variety of human cancers, including hepatocellular carcinoma. However, resistance to its growth inhibitory effects is common. We hypothesized that hepatic cell lines with varying rapamycin responsiveness would show common characteristics accounting for resistance to the drug.We profiled a ...
Jimenez RH, Boylan JM, Lee JS, FRANCESCONI, MIRKO, CASTELLANI, GASTONE, Sanders JA, Gruppuso PA   +6 more
openaire   +4 more sources

NMI inhibits cancer stem cell traits by downregulating hTERT in breast cancer. [PDF]

, 2017
N-myc and STAT interactor (NMI) has been proved to bind to different transcription factors to regulate a variety of signaling mechanisms including DNA damage, cell cycle and epithelial-mesenchymal transition. However, the role of NMI in the regulation of
Chen, Yiming, Deng, Wuguo, Feng, Xu, Gao, Yue, Guo, Wei, Hao, Jiaojiao, Huang, Wenlin, Kang, Lan, Liao, Yina, Tang, Ranran, Wu, Jiali, Xiao, Xiangsheng, Xu, Xiangdong, Yu, Wendan, Zhao, Xinrui, Zou, Kun   +15 more
core   +1 more source

Neoplastic transformation of mouse C3H 10T1/2 and Syrian hamster embryo cells by heavy ions [PDF]

, 1989
C3H 10T1/2 mouse-embryo fibroblasts were used for transformation experiments to study the effectiveness of various heavy ions with energies up to 20 MeV/u and LET values from 170 to 16.000 keV/μm.
A.M. Kellerer, Balcer-Kubiczek, Barendsen, Borek, Borek, Chomczynski, G. Ponsel, Hall, Han, Han, Hieber, Hill, K. Trutschler, Kraft, L. Hieber, Lloyd, Miller, Miller, Reznikoff, Robertson, S. Fenn, Schaeffer, Terzaghi, Wulf, Yang   +24 more
core   +1 more source

Assessment of Tumorigenic Potential in Mesenchymal-Stem/Stromal-Cell-Derived Small Extracellular Vesicles (MSC-sEV)

Pharmaceuticals, 2021
Mesenchymal-stem/stromal-cell-derived small extracellular vesicles (MSC-sEV) have been shown to ameliorate many diseases in preclinical studies. However, translating MSC-sEV into clinical use requires the development of scalable manufacturing processes ...
Thong Teck Tan, Ruenn Chai Lai, Jayanthi Padmanabhan, Wei Kian Sim, Andre Boon Hwa Choo, Sai Kiang Lim   +5 more
doaj   +1 more source

Immunocompetent murine models for the study of glioblastoma immunotherapy. [PDF]

, 2014
Glioblastoma remains a lethal diagnosis with a 5-year survival rate of less than 10%. (NEJM 352:987-96, 2005) Although immunotherapy-based approaches are capable of inducing detectable immune responses against tumor-specific antigens, improvements in ...
Bloch, Orin, Clark, Aaron J, Fakurnejad, Shayan, Ivan, Michael E, James, Charles D, Oh, Taemin, Parsa, Andrew T, Safaee, Michael, Sayegh, Eli T, Sun, Matthew Z   +9 more
core   +2 more sources