Results 41 to 50 of about 9,895 (265)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

DNS Study of Effects of Suddenly-Vanishing Wall Heating in Turbulent Boundary Layer

Journal of Thermal Science and Technology, 2012
The objective of this study is to investigate a thermal field in the turbulent boundary layer by means of direct numerical simulation (DNS), in which the wall heating has suddenly vanished in the downstream region, i.e., the wall is heated by a constant ...
Hirofumi HATTORI, Syohei YAMADA, Tomoya HOURA   +2 more
doaj   +1 more source

Turbulent boundary layer equations [PDF]

Comptes Rendus. Mathématique, 2002
We study a boundary layer problem for the Navier–Stokes-alpha model obtaining a generalization of the Prandtl equations which we conjecture to represent the averaged flow in a turbulent boundary layer. We study the equations for the semi-infinite plate, both theoretically and numerically.
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Amplitude modulated near-wall cycle in a turbulent boundary layer under an adverse pressure gradient

Archives of Mechanics, 2013
This paper presents the effect of amplitude modulation of small-scale turbulence by large-scale structures in a turbulent boundary layer subjected to an adverse pressure gradient.
A. Dróżdż, W. Elsner
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Response of the Land‐Atmosphere System Over North‐Central Oklahoma During the 2017 Eclipse

Geophysical Research Letters, 2018
On 21 August 2017, a solar eclipse occurred over the continental United States resulting in a rapid reduction and subsequent increase of solar radiation over a large region of the country.
D. D. Turner, V. Wulfmeyer, A. Behrendt, T. A. Bonin, A. Choukulkar, R. K. Newsom, W. A. Brewer, D. R. Cook   +7 more
doaj   +1 more source

Boundary-layer turbulent processes and mesoscale variability represented by numerical weather prediction models during the BLLAST campaign [PDF]

Atmospheric Chemistry and Physics, 2016
This study evaluates the ability of three operational models, with resolution varying from 2.5 to 16 km, to predict the boundary-layer turbulent processes and mesoscale variability observed during the Boundary Layer Late-Afternoon and Sunset ...
F. Couvreux, E. Bazile, G. Canut, Y. Seity, M. Lothon, F. Lohou, F. Guichard, E. Nilsson   +7 more
doaj   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source