Results 111 to 120 of about 122,095 (310)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
LES and RANS for turbulent flow over arrays of wall-mounted obstacles
, 2006 Large-eddy simulation (LES) has been applied to calculate the turbulent flow over staggered wall-mounted cubes and staggered random arrays of obstacles with area density 25%, at Reynolds numbers between 5 × 10^3 and 5 10^6, based on the free stream ...
Zhengtong Xie +3 more
core +1 more source
Teshugang, 2007 Tempered martensite can be formed at surface of bar to increase its mechanical properties by higher efficient tube type turbulent flow cooling system after hot rolling of bar products.
晋艳娟 +4 more
doaj
Tribology Online, 2007 This paper presents a general theoretical approach to evaluate the leakage flow, stiffness and damping of annular seals in turbulent flow regime including fluid inertia using turbulent lubrication theory.
Satyam Shivam Gautam, Mihir Kumar Ghosh
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Conditional moment closures for turbulent reacting flows [PDF]
, 2003 Mathematical modelling of the turbulent combustion process is becoming increasingly applied in calculations to assist in the design and analysis of practical combustion devices for efficiency-improvement and emission reduction. The current requirement to
Woolley, Robert Michael
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
How vegetation in flows modifies the turbulent mixing and spreading of jets
Scientific Reports, 2017 While studies on vegetated channel flows have been developed in many research centers, studies on jets interacting with vegetation are still rare.
Michele Mossa +3 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source