Results 61 to 70 of about 455,438 (280)
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Master-modes in 3D turbulent channel flow [PDF]
, 2008 Turbulent flow fields can be expanded into a series in a set of basic functions. The terms of such series are often called modes. A master- (or determining) mode set is a subset of these modes, the time history of which uniquely determines the time ...
Bondarenko, Maksym, Chernyshenko, Sergei
core +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Hydrodynamics of the Cylinder Rotating in the Unbounded Viscous Medium
Механика машин, механизмов и материалов, 2009 It is shown, that at first a laminar flow around rotating cylinder with growth of Reynolds number passes into a pseudo-laminar flow, and then into a steady turbulent flow.
Ed.A. Bulanov
doaj
On the applicability of Taylor's hypothesis in streaming magnetohydrodynamic turbulence
, 2019 We examine the range of applicability of Taylor's hypothesis used in observations of magnetic turbulence in the solar wind. We do not refer to turbulence theory.
Baumjohann, W. +2 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Measurements of the magnetic field induced by a turbulent flow of liquid metal
, 2005 Initial results from the Madison Dynamo Experiment provide details of the inductive response of a turbulent flow of liquid sodium to an applied magnetic field. The magnetic field structure is reconstructed from both internal and external measurements.
Bourgoin M. +11 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Scalar Transport Characteristics Near the Turbulent/Non-Turbulent Interface in a Reactive Jet Flow
气体物理Turbulent/non-turbulent interface (T/NTI) layer separates the turbulent and non-turbulent regions. The study of T/NTI is helpful to deepen the understanding of mass transfer between turbulent and non-turbulent regions.
Qingqing CAO +3 more
doaj +1 more source
Mass and Momentum Turbulent Transport Experiments [PDF]
, 1983 The downstream mixing of coaxial jets discharging in an expanded duct was studied to improve turbulent transport models which are used in computational procedures throughout the propulsion community for combustor flow modeling. Laser velocimeter (LV) and
Johnson, B. V.
core +1 more source