Results 81 to 90 of about 5,905 (264)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

ESTIMATION OF MIXING AND TRANSFORMATION OF SOUTH PACIFIC WATER MASSES IN THE HALMAHERA SEA: ESTIMASI PERCAMPURAN DAN TRANSFORMASI MASSA AIR PASIFIK SELATAN DI LAUT HALMAHERA

Jurnal Teknologi Perikanan dan Kelautan
The Halmahera Sea is part of the eastern pathway of Indonesian Throughflow and is a key area for water mass interaction and transformation. This study aims to estimate vertical mixing and analyze its implications for South Pacific water masses ...
Jesikha Dwi Aprilia, Yuli Naulita, I Wayan Nurjaya, Adi Purwandana, Zheng Wang   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Numerical experiments on scalar transport and mixing in turbulent boundary layers

Journal of Physics: Conference Series
Abstract In this work, we present numerical experiments aimed at dynamically establishing the separate role of the inner and outer cycles on the scalar transport in the configuration of a temporally evolving boundary layer. The experiments are based on the study of the evolution of passive scalars driven by velocity fields where inner ...
Gabriele Boga, Alfonso Giancola, Andrea Cimarelli   +2 more
openaire   +1 more source

Three-layer circulation in the world deepest hadal trench

Nature Communications
The Challenger Deep (CD) is the deepest known hadal trench in the world. Due to challenges in data sampling at extreme ocean depths, the Lower Circumpolar Deep Water (LCDW) transport and ocean circulation structure in the CD remain unclear.
Huichang Jiang, Xiao Xin, Hongzhou Xu, Chun Zhou, Philip A. Vetter, Liu Yu, Tong Long, Qi’an Chen, Jiwei Tian   +8 more
doaj   +1 more source

Impact of Internal Solitary Waves on Marine Suspended Particulate Matter: A Review

Journal of Marine Science and Engineering
Suspended particulate matter (SPM) plays a pivotal role in marine source-to-sink sedimentary systems. Internal solitary waves (ISWs), a prevalent hydrodynamic phenomenon, significantly influence vertical mixing, cross-shelf material transport, and ...
Zhengrong Zhang, Xuezhi Feng, Xiuyao Fan, Yuchen Lin, Chaoqi Zhu   +4 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Experimental studies of Reynolds number dependence of turbulent mixing and transport [PDF]

, 1994
Predicting turbulent mixing and transport remains a critical problem in industrial flows (combustion chambers, mixers, ventillation systems etc.) and in the environment (smoke plumes etc.). The mixing and transport processes are often a strong function of Reynolds number (Re) and yet there is a paucity of information on their Re dependence.
openaire   +2 more sources