Results 81 to 90 of about 113,224 (304)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The structure of the solution obtained with Reynolds-stress-transport models at the free-stream edges of turbulent flows [PDF]

, 2002
The behavior of Reynolds-stress-transport models at the free-stream edges of turbulent flows is investigated. Current turbulent-diffusion models are found to produce propagative (possibly weak) solutions of the same type as those reported earlier by ...
Cazalbou, Jean-Bernard, Chassaing, Patrick   +1 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Himawari sea surface temperature data reveal regular internal wave activity producing cooling in the northern South China Sea

Frontiers in Marine Science
Internal wave (IW) events occur rapidly and have a short duration, but they have a great impact on nearshore ecosystems. To address the problems of short observation time, limited range based on measured data, and low accuracy based on mesoscale ...
Xiaoyan Dang, Yi Sui, Danling Tang, Jiujuan Wang, Shengli Chen   +4 more
doaj   +1 more source

Mass and Momentum Turbulent Transport Experiments [PDF]

An experimental study of mixing downstream of axial and swirling coaxial jets is being conducted to obtain data for the evaluation and improvement of turbulent transport models currently employed in a variety of computational procedures used throughout ...
Johnson, B. V., Roback, R.
core   +1 more source

Resonance enhanced turbulent transport [PDF]

, 2007
The effect of oscillatory shear flows on turbulent transport of passive scalar fields is studied by numerical computations based on the results provided by E. Kim [Physics of Plasmas 13, 022308 (2006)] .
Andrew P. L. Newton, Eun-jin Kim, Kichatinov L. L., Stoker J.   +3 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Experimental and numerical investigations of flow structure and momentum transport in a turbulent buoyancy-driven flow inside a tilted tube. [PDF]

, 2009
Buoyancy-driven turbulent mixing of fluids of slightly different densities [At = Δρ/(2〈ρ〉) = 1.15×10−2] in a long circular tube tilted at an angle θ = 15° from the vertical is studied at the local scale, both experimentally from particle image ...
Birman V. K., D. Salin, E. J. Hinch, F. Moisy, J. Magnaudet, J. P. Hulin, J. Znaien, Johnston J. P., Schlichting H., Seon T., Simpson J. E., Y. Hallez   +11 more
core   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Interacting internal waves explain global patterns of interior ocean mixing

Nature Communications
Across the stable density stratification of the abyssal ocean, deep dense water is slowly propelled upward by sustained, though irregular, turbulent mixing.
Giovanni Dematteis, Arnaud Le Boyer, Friederike Pollmann, Kurt L. Polzin, Matthew H. Alford, Caitlin B. Whalen, Yuri V. Lvov   +6 more
doaj   +1 more source