Results 101 to 110 of about 4,220,519 (287)

Automatic Conflict Detection in Police Body-Worn Audio

open access: yes, 2018
Automatic conflict detection has grown in relevance with the advent of body-worn technology, but existing metrics such as turn-taking and overlap are poor indicators of conflict in police-public interactions. Moreover, standard techniques to compute them
Cademartori, Collin   +4 more
core   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Pragmatic functions of lengthenings and filled pauses in the adult-directed speech of Hungarian children [PDF]

open access: yes, 2013
Two most common disfluencies of spontaneous speech, vowel lengthenings (VLE) and non-lexicalized filled pauses (NLFP) were investigated in the adult-directed speech of eight Hungarian children.
Deme, Andrea
core  

Cluster varieties from Legendrian knots

open access: yes, 2018
Many interesting spaces --- including all positroid strata and wild character varieties --- are moduli of constructible sheaves on a surface with microsupport in a Legendrian link.
Shende, Vivek   +3 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Not-So-Simple Stellar Populations in the Intermediate-age Large Magellanic Cloud Star Clusters NGC 1831 and NGC 1868

open access: yes, 2013
Using a combination of high-resolution Hubble Space Telescope/WFPC2 observations, we explore the physical properties of the stellar populations in two intermediate-age star clusters in the Large Magellanic Cloud, NGC 1831 and NGC 1868, based on their ...
de Grijs, Richard   +2 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy