Results 91 to 100 of about 4,220,519 (287)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The excitation operator approach to non-Markovian dynamics of quantum impurity models in the Kondo regime

, 2012
We present a numerical method for studying the real time dynamics of a small interacting quantum system coupled to an infinite fermionic reservoir. By building an orthonormal basis in the operator space, we turn the Heisenberg equation of motion into a ...
Wang, Pei
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Taking it in turn: an experimental test of theories of the household [PDF]

Using a sample of established couples, we conduct an experiment on household decision-making. Individual partners first make a series of dichotomous choices between household goods and vouchers for experiences and then the couple jointly face the same ...
McNally, Tara, Munro, Alistair, Popov, Danail   +2 more
core   +1 more source

Massive fields temper anomaly-induced inflation: the clue to graceful exit?

, 2001
A method of calculating the vacuum effective action for massive quantum fields in curved space-time is outlined. Our approach is based on the conformal representation of the fields action and on the integration of the corresponding conformal anomaly.
Anderson, Balbinot, Balbinot, Buchbinder, Buchbinder, Buchmuller, Coleman, Coughlan, Deser, Duff, Ellis, Fabris, Fabris, Fischetti, Fradkin, Guth, Haber, Hawking, Helayel-Neto, Ilya L. Shapiro, Joan Solà, Koyama, Lahanas, Mamaev, Nilles, Peccei, Reigert, Shapiro, Shapiro, Shapiro, Solà, Solà, Starobinski, Starobinski, Starobinski, Tomboulis, Vilenkin, Weinberg, Wetterich, Witten   +39 more
core   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Irreversibility line and low-field grain-boundary pinning in electron-doped superconducting thin films

, 2007
AC magnetic susceptibilities of electron-doped Pr_{1.85}Ce_{0.15}CuO_4 (PCCO) and Sm_{1.85}Ce_{0.15}CuO_4 (SCCO) granular thin films have been measured as a function of temperature and magnetic-field strength. Depending on the level of homogeneity of our
A. J. C. Lanfredi, F. M. Araujo-Moreira, Hein R. A., S. Sergeenkov   +3 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Unconscious gestures that empower turn taking for telepresence robot

Nihon Kikai Gakkai ronbunshu, 2014
In this research, we propose a telepresence robot that avoids speech collisions occurs in remote conversations. In face-to-face conversations, humans predict the next speaker by seeing others' gestures.
Komei HASEGAWA, Yasushi NAKAUCHI
doaj   +1 more source