Results 81 to 90 of about 3,863,027 (241)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Respiratory turn-taking cues [PDF]
, 2016 This paper investigates to what extent breathing can be used as a cue to turn-taking behaviour. The paper improves on existing accounts by considering all possible transitions between speaker states (silent, speaking, backchanneling) and by not relying ...
Heldner, Mattias, +5 more
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Gaze patterns in turn-taking [PDF]
, 2013 Oertel C, Wlodarczak M, Edlund J, Wagner P, Gustafson J. Gaze patterns in turn-taking. In: 13th Annual Conference of the International Speech Communication Association 2012 (INTERSPEECH 2012).
Wagner, Petra ; https://orcid.org/ +4 more
core
Unconscious gestures that empower turn taking for telepresence robot
Nihon Kikai Gakkai ronbunshu, 2014 In this research, we propose a telepresence robot that avoids speech collisions occurs in remote conversations. In face-to-face conversations, humans predict the next speaker by seeing others' gestures.
Komei HASEGAWA, Yasushi NAKAUCHI
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Predicting the Micro-Timing of User Input for an Incremental Spoken Dialogue System that Completes a User's Ongoing Turn [PDF]
, 2011 Baumann T, Schlangen D. Predicting the Micro-Timing of User Input for an Incremental Spoken Dialogue System that Completes a User's Ongoing Turn.
Schlangen, David +2 more
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source