Results 111 to 120 of about 4,517,907 (325)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

CRISIS AND THE INTERCONNECTIONS BETWEEN WORLD’S ECONOMIES [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2010
This paper has like primary objective to present the crisis that hit the global economy since 1929 and the interconnections between different regions and countries.
Emilia Ungureanu   +1 more
doaj  

Most probable transition path in an overdamped system for a finite transition time

open access: yes, 2006
The most probable transition path in a one-dimensional overdamped system is rigorously proved to possess less than two turning points.
Dykman   +19 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

THE BALTIC PERSPECTIVES OF ESTONIAN TURNING POINTS [PDF]

open access: yesActa Historica Tallinnensia, 2000
Rein Taagepera
doaj   +1 more source

Exploring the turning points in researchers’ lives: using the three-scene storyboarding technique [PDF]

open access: yes, 2013
This publication sets out an approach to careers work called three scene storyboarding. Storyboarding aims to help researchers to set down their experiences, to think about their careers and to take action based on this reflection.
Bentley, Kieran   +2 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Impact of Growing Public Debt on Economic Growth in the European Union

open access: yesAmfiteatru Economic, 2014
The paper attempts to empirically explore the transmission mechanism regarding the short-term impact of public debt and growth. We examine and evaluate the direct effect of higher indebtedness on economic growth for countries in the EU which are in the ...
Jernej Mencinger   +2 more
doaj  

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