Results 81 to 90 of about 707,579 (129)

Comparison of two twin-screw extruders for continuous granulation

, 2009
A comparison was made between two twin-screw extruders (APV Baker and Leistritz Micro) used for continuous wet granulation. Both extruders had similar screw configurations, based on the length-to-diameter ratio of the screws, existing out of a conveying ...
Remon, Jean Paul, Djuric, Dejan, Van Melkebeke, Barbara, Vervaet, Chris, Kleinebudde, Peter   +4 more
core   +1 more source

Managing API raw material variability during continuous twin-screw wet granulation

, 2019
Very few studies have investigated the impact of raw material variability upon the granule critical quality attributes (CQAs) produced via twin-screw wet granulation (i.e., granule size distribution, density, flowability).
Chavez, Pierre-François, Pilcer, G, De Beer, Thomas, Vervaet, Chris, Vanhoorne, Valérie, Stauffer, Fanny   +5 more
core   +1 more source

Native starch as in situ binder for continuous twin screw wet granulation

, 2019
The use of native starch as in situ binder in a continuous twin screw wet granulation process was studied. Gelatinization of pea starch occurred in the barrel of the granulator using a poorly soluble excipient (anhydrous dicalcium phosphate), but the ...
Vandevivere, Lise0001611491308020024530259737173742440000-0003-4677-35386D13BC70-81D9-11E6-9883-EC8EB5D1D7B1, Vanhoorne, ValérieFW010000605256738020010479390000-0003-4249-34080276C59A-F0EE-11E1-A9DE-61C894A0A6B4, Portier, Christoph, De Beer, Thomas, Vervaet, Chris, Vanhoorne, Valérie, Vervaet, ChrisFW010019871419968010008673970000-0002-1291-6054F4A465E4-F0ED-11E1-A9DE-61C894A0A6B4, Häusler, Olaf, Portier, ChristophFW020000903288248020020592640000-0001-5065-27421F545416-F0EE-11E1-A9DE-61C894A0A6B4, Vandevivere, Lise, Simon, Denis, De Beer, ThomasFW020019972147418010016996780000-0001-6296-0443F69EB3AE-F0ED-11E1-A9DE-61C894A0A6B4   +11 more
core   +1 more source

Development and evaluation of a continuous granulation technique using a twin-screw extruder

, 2009
The term granulation refers to a process of size-enlargement, whereby primary powder particles are gathered into larger, semi-permanent aggregates (granules) in which the original particles still can be identified. The main reasons for granulation in the
Van Melkebeke, Barbara
core  

Compartmental approach for modelling twin-screw granulation using population balances

, 2019
In this study, a compartmental population balance model (CPBM) is developed as a predictive tool of particle size distribution (PSD) for wet granulation in co-rotating twin-screw granulator (TSG).
Walker, Gavin M., Singh, Mehakpreet, Gavin M. Walker (6001025), Darren Whitaker (7008746), Shirazian, Saeed, Hamza Y. Ismail (7525715), Saeed Shirazian (8991146), Mehakpreet Singh (12350701), Ismail, Hamza Y., Whitaker, Darren, Ahmad B. Albadarin (7525718), Albadarin, Ahmad B.   +11 more
core  

Characterizing a design space for a twin-screw wet granulation process: A case study of extended-release tablets. [PDF]

Int J Pharm
Sierra-Vega NO, Alsharif FM, O'Connor T, Ashraf M, Zidan A.   +4 more
europepmc   +1 more source

Optimization of critical quality attributes in continuous twin-screw wet granulation via design space validated with pilot scale experimental data. [PDF]

Int J Pharm, 2017
Liu H, Galbraith SC, Ricart B, Stanton C, Smith-Goettler B, Verdi L, O'Connor T, Lee S, Yoon S.   +8 more
europepmc   +1 more source

Metamorphosis of Twin Screw Extruder-Based Granulation Technology: Applications Focusing on Its Impact on Conventional Granulation Technology. [PDF]

AAPS PharmSciTech, 2021
Rao RR, Pandey A, Hegde AR, Kulkarni VI, Chincholi C, Rao V, Bhushan I, Mutalik S.   +7 more
europepmc   +1 more source

Optimization of screw design for continuous wet granulation: A case study of metoprolol succinate ER tablets. [PDF]

Int J Pharm, 2022
Zidan A, Kotamarthy L, Ramachandran R, Ashraf M, O'Connor T.   +4 more
europepmc   +1 more source

Formulation Design of Amiodarone Hydrochloride Tablets Optimized for a Continuous Manufacturing Process. [PDF]

Pharmaceutics
Yoon JH, Jeon CW, Park YJ, Kim JE.
europepmc   +1 more source