Results 1 to 10 of about 707,337 (64)

Application of I-Optimal Design for Modeling and Optimizing the Operational Parameters of Ibuprofen Granules in Continuous Twin-Screw Wet Granulation [PDF]

Biomedicines, 2023
The continuous twin-screw wet granulation (TSWG) process was investigated and optimized with prediction-oriented I-optimal designs. The I-optimal designs can not only obtain a precise estimation of the parameters that describe the effect of five input ...
Jie Zhao, Geng Tian, Haibin Qu
doaj   +5 more sources

Pharmaceutical Application of Process Understanding and Optimization Techniques: A Review on the Continuous Twin-Screw Wet Granulation [PDF]

Biomedicines, 2023
Twin-screw wet granulation (TSWG) is a method of continuous pharmaceutical manufacturing and a potential alternative method to batch granulation processes.
Jie Zhao, Geng Tian, Haibin Qu
doaj   +5 more sources

Evaluation of Polyvinyl Alcohol as Binder during Continuous Twin Screw Wet Granulation [PDF]

Pharmaceutics
Binder selection is a crucial step in continuous twin-screw wet granulation (TSWG), as the material experiences a much shorter residence time (2–40 s) in the granulator barrel compared to batch-wise granulation processes. Polyvinyl alcohol (PVA) 4-88 was
Phaedra Denduyver, Gudrun Birk, Alessandra Ambruosi, Chris Vervaet, Valérie Vanhoorne   +4 more
doaj   +5 more sources

Development of a Rapid Method for Residence Time Distribution Measurement in Twin-Screw Wet Granulation Based on Image Processing with Lab Color Space [PDF]

Pharmaceutics
Background/Objectives: In the twin-screw wet granulation (TSWG) process, accurate measurement of residence time distribution (RTD) is critical, as it characterizes material transport kinetics and mixing behavior.
Jie Zhao, Geng Tian, Ying Tian, Haibin Qu   +3 more
doaj   +5 more sources

A Material–Process–Equipment Integrated Design Method for Accelerating the Process Development of Twin-Screw Wet Granulation [PDF]

Pharmaceuticals
Background: Twin-screw wet granulation (TSWG) is a promising continuous manufacturing technology, featuring high operational flexibility, short residence time and consistent quality.
Liping Chen, Wuzhen Qi, Juntao Xie, Yidan Wang, Shuying Zhao, Xiao Ma, Yifan Hu, Hui Jiang, Ying Liu, Bing Xu   +9 more
doaj   +2 more sources

Optimization of Critical Quality Attributes in Continuous Twin-Screw Wet Granulation via Design Space Validated With Pilot Scale Experimental Data [PDF]

International Journal of Pharmaceutics, 2017
Huolong Liu, Seongkyu Yoon, Thomas O'Connor   +2 more
exaly   +2 more sources

Discrete element method simulation of a twin screw wet granulator [PDF]

EPJ Web of Conferences
Granulation is a method of particle size enlargement via agglomeration of primary particles to form larger particles. In a Twin Screw Wet Granulator (TSWG), a binder liquid is sprayed onto the surfaces of active pharmaceutical ingredient particles to ...
Iyer Kiran, Wang Yu, Esteghamatian Amir, Meyer Ewald Jonathan, Doshi Pankaj, Wee Chuan Lim Eldin   +5 more
doaj   +1 more source

Integrated Continuous Wet Granulation and Drying: Process Evaluation and Comparison with Batch Processing. [PDF]

Pharmaceutics, 2023
Forster SP, Dippold E, Haser A, Emanuele D, Meier R.   +4 more
europepmc   +1 more source

Metamorphosis of Twin Screw Extruder-Based Granulation Technology: Applications Focusing on Its Impact on Conventional Granulation Technology. [PDF]

AAPS PharmSciTech, 2021
Rao RR, Pandey A, Hegde AR, Kulkarni VI, Chincholi C, Rao V, Bhushan I, Mutalik S.   +7 more
europepmc   +1 more source

Improvement of a 1D Population Balance Model for Twin-Screw Wet Granulation by Using Identifiability Analysis. [PDF]

Pharmaceutics, 2021
Barrera Jiménez AA, Van Hauwermeiren D, Peeters M, De Beer T, Nopens I.   +4 more
europepmc   +1 more source