Results 21 to 30 of about 707,337 (64)

Twin Screw Granulation – A Literature Review [PDF]

, 2015
This review article addresses the currently available literature on Twin Screw Granulation (TSG). TSG is an emerging technology rapidly gaining interest in the pharmaceutical industry as a method of continuous wet granulation. The control of the geometry
Gabbott, Ian, De Matas, Marcel, Huang, Zhenyu, Rowson, Neil A., Reynolds, Gavin K., Ingram, Andrew, Chan Seem, Timothy, Yu, Shen   +7 more
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Linking granulation performance with residence time and granulation liquid distributions in twin-screw granulation: An experimental investigation [PDF]

, 2016
Twin-screw granulation is a promising wet granulation technique for the continuous manufacturing of pharmaceutical solid dosage forms. A twin screw granulator displays a short residence time.
Remon, Jean Paul, De Beer, Thomas, Ketolainen, Jarkko, Vervaet, Chris, Gernaey, Krist V., Nopens, Ingmar, Vanhoorne, Valérie, De Leersnyder, Fien, Juuti, Mikko, Vercruysse, Jurgen, Kumar, Ashish, Alakarjula, Maija, Toiviainen, Maunu   +12 more
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Wet Granulation in a Twin Screw Extruder [PDF]

, 2008
This thesis covers a systematic examination of wet granulation in a twin screw extruder. Granulation of the excipient, (alpha)-lactose monohydrate, was done with the aid of PVP in an aqueous solution which acted as a binding agent.
Sun, Junfeng
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Mechanistic modeling of twin screw wet granulation for pharmaceutical formulations : calibration, sensitivity analysis, and model-driven workflow [PDF]

Wet granulation, a particle size enlargement process, can significantly enhance the critical quality attributes of powders and improve the ability to form tablets in pharmaceutical manufacturing.
Lee, Kai, Dawson, Neil, Iyer, Kiran, Schongut, Marek, Doshi, Pankaj, Ahmed, Bilal, Smith, Rachel M., Bala, Neeru, Corrigan, Jeremiah, Meyer, Jonathan, Rowland, Martin, Litster, James D.   +11 more
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An advanced twin‑screw granulation technology: the use of non‑volatile solvents with high solubilizing capacity [PDF]

Purpose Twin-screw wet granulation (TSWG) is a manufacturing process that ofers several advantages for the processing of water-insoluble active pharmaceutical ingredients (APIs) and has been used for increasing the solubility and dissolution rates ...
Kolipaka, Siva Satyanarayana, Junqueira, Laura Andrade, Mithu, Md Sadeque Hossain, Ross, Steven, Bhatt, Saumil, Garg, Vivek, Douroumis, Dionysios   +6 more
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Continuous granulation

, 2021
This chapter discusses the continuous processing of pharmaceutical solid dosage forms, focusing on continuous wet granulation. Based on the advantages offered by continuous manufacturing, it highlights the drivers for the pharmaceutical industry to shift
Thomas De Beer, De Beer, Thomas, Vervaet, Chris, Vanhoorne, Valérie, Chris Vervaet, Valérie Vanhoorne   +5 more
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TWIN SCREW GRANULATION: UNDERSTANDING THE MECHANICAL PROPERTIES OF PHARMACEUTICAL EXCIPIENTS FROM POWDER TO TABLET [PDF]

, 2018
The overall aim of this work is to understand the effect of the mechanical properties of the primary powder and the granulation process on granules and tablets properties, most importantly tablet tensile strength.
Khorsheed, Bilal
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Critical material attributes during continuous twin-screw wet granulation

Twin-screw wet granulation (TSWG) has evolved in recent years into a mature, effective, and widely adopted technique. This has been accompanied by an enhanced understanding of the process through the identification of critical process parameters (CPPs ...
Vervaet, Chris, Vanhoorne, Valérie, Denduyver, Phaedra   +2 more
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Analysis of the effect of formulation properties and process parameters on granule formation in twin-screw wet granulation

In the last few years, twin-screw wet granulation (TSWG) has become one of the key continuous pharmaceutical unit operations. Despite the many studies that have been performed, only little is known about the effect of the starting material properties on ...
Matsunami, KensakuFW020001907414068020037291790000-0002-8831-018Xfa74b9bb-f129-11e9-843f-92d8df47a88d, dos Santos Schultz, Eduardo, Barrera Jiménez, Ana Alejandra00018151286480200299026297498991502254E10A42-C5C8-11E8-8987-A2685607D3EF, Nopens, IngmarLA260019942824128010013710900000-0001-6670-3700F5D054AA-F0ED-11E1-A9DE-61C894A0A6B4, Vigh, Tamas, Roudgar, Mina, Peeters, Michiel0001412872678020029468169771395764781DF01E9E-9DD4-11E4-99AF-9C7DB5D1D7B1, Stauffer, Fanny, Ghijs, MichaelFW020000905303028020019244740000-0002-6398-88162404E3A4-F0EE-11E1-A9DE-61C894A0A6B4, De Beer, ThomasFW020019972147418010016996780000-0001-6296-0443F69EB3AE-F0ED-11E1-A9DE-61C894A0A6B4   +9 more
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Wet granulation in laboratory scale high shear mixers: Effect of binder properties [PDF]

, 2011
The effect of binder properties on torque curves, granule growth kinetics, wet mass consistency and dry granule strength has been investigated in this study.
Hemati, Mehrdji, M. Hemati, Oulahna, Driss, T.M. Chitu, D. Oulahna, Chitu, Toma Mihai   +5 more
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