Continuous Twin Screw Granulation: A Review of Recent Progress and Opportunities in Formulation and Equipment Design [PDF]
Pharmaceutics, 2021 Continuous twin screw wet granulation is one of the key continuous manufacturing technologies that have gained significant interest in the pharmaceutical industry as well as in academia over the last ten years.
Christoph Portier +2 more
exaly +5 more sources
Advances in Twin-Screw Granulation Processing [PDF]
Pharmaceutics, 2021 Twin-screw granulation (TSG) is a pharmaceutical process that has gained increased interest from the pharmaceutical industry for its potential for the development of oral dosage forms.
Uttom Nandi +3 more
doaj +3 more sources
Advances in Twin-Screw Granulation [PDF]
Pharmaceutics, 2021 Twin-screw granulation (TSG) is an emerging process technology that allows both wet and dry granulation of powders with a wide range of properties [...]
Valérie Vanhoorne, Ashish Kumar
doaj +3 more sources
Continuous twin screw granulation: Impact of microcrystalline cellulose batch-to-batch variability during granulation and drying – A QbD approach [PDF]
International Journal of Pharmaceutics: X, 2021 Despite significant advances in the research domain of continuous twin screw granulation, limited information is currently available on the impact of raw material properties, especially considering batch-to-batch variability.
Christoph Portier +7 more
doaj +3 more sources
Process Simulation of Twin-Screw Granulation: A Review [PDF]
PharmaceuticsTwin-screw granulation has emerged as a key process in powder processing industries and in the pharmaceutical sector to produce granules with controlled properties.
Tony Bediako Arthur, Nejat Rahmanian
doaj +3 more sources
Continuous twin screw granulation – An advanced alternative granulation technology for use in the pharmaceutical industry [PDF]
International Journal of Pharmaceutics, 2020 Hot melt extrusion has been an exciting technology in the pharmaceutical field owing to its novel applicability. Twin-screw granulation presents a great potential and offers many advantages relative to conventional granulation processes.
Suresh Bandari +2 more
exaly +3 more sources
A Semi-Mechanistic Prediction of Residence Time Metrics in Twin Screw Granulation [PDF]
Pharmaceutics, 2021 This work is concerned with the semi-mechanistic prediction of residence time metrics using historical data from mono-component twin screw wet granulation processes.
Shashank Venkat Muddu +2 more
doaj +3 more sources
Optimizing Energy Efficiency of a Twin-Screw Granulation Process in Real-Time Using a Long Short-Term Memory (LSTM) Network [PDF]
ACS Engineering Au, 2023 Traditional pharmaceutical manufacturing processes for solid oral dosage forms can be inefficient and have been known to produce a large amount of undesired product.
Chaitanya Sampat, Rohit Ramachandran
doaj +3 more sources
Twin-screw granulation – a systematic analysis of process parameters [PDF]
British Journal of Pharmacy, 2018 Twin-screw granulation has a significant advantage over traditional granulation methods leading to the possibility of continuous manufacturing. Although this technology has drawn attention in recent years, the general understanding of the process is ...
Margarethe Richter
doaj +3 more sources
Twin-Screw Melt Granulation for Oral Solid Pharmaceutical Products
Pharmaceutics, 2021 This article highlights the advantages of pharmaceutical continuous melt granulation by twin-screw extrusion. The different melt granulation process options and excipients are described and compared, and a case is made for expanded use of twin-screw melt
Seth P Forster, Erin Dippold
exaly +3 more sources