Results 41 to 50 of about 19,781 (230)
Predicting pharmaceutical particle size distributions using kernel mean embedding [PDF]
, 2020 In the pharmaceutical industry, the transition to continuous manufacturing of solid dosage forms is adopted by more and more companies. For these continuous processes, high-quality process models are needed.
De Beer, Thomas +3 more
core +1 more source
Distribution of binder in granules produced by means of twin screw granulation [PDF]
International Journal of Pharmaceutics, 2014 According to the quality by design principle processes may not remain black-boxes and full process understanding is required. The granule size distribution of granules produced via twin screw granulation is often found to be bimodal. The aim of this study was to gain a better understanding of binder distribution within granules produced via twin screw ...
Margot Fonteyne +7 more
openaire +4 more sources
Predicting the particle size distribution in twin screw granulation through acoustic emissions
Powder Technology, 2021 A non-destructive process analytical technology for monitoring the complex particle size distributions inherent to twin screw granulation (TSG) was presented, based on acoustic emissions (AE).
H. Abdulhussain, M. Thompson
semanticscholar +1 more source
Continuous Melt Granulation for Taste-Masking of Ibuprofen
Pharmaceutics, 2021 Taste-masking of drugs, particularly to produce formulations for pediatric patients, can be challenging and require complex manufacturing approaches. The objective of this study was to produce taste-masked ibuprofen granules using a novel process, twin ...
Seth P. Forster, David B. Lebo
doaj +1 more source
Real-time assessment of critical quality attributes of a continuous granulation process [PDF]
, 2013 There exists the intention to shift pharmaceutical manufacturing of solid dosage forms from traditional batch production towards continuous production. The currently applied conventional quality control systems, based on sampling and time-consuming off ...
Córdoba Díaz, Damián +6 more
core +1 more source
European journal of pharmaceutics and biopharmaceutics, 2021 This study demonstrated the first case of combining a novel continuous granulation technique with powder-bed fusion-based selective laser sintering (SLS) process to enhance the dissolution rate and physical properties of a poorly water-soluble drug ...
Rishi Thakkar +3 more
semanticscholar +1 more source
Pharmaceutics, 2021 Recently, the pharmaceutical industry has undergone changes in the production of solid oral dosages from traditional inefficient and expensive batch production to continuous manufacturing.
Ana Alejandra Barrera Jiménez +4 more
doaj +1 more source
Quantitative Assessment of Mass Flow Boundaries in Continuous Twin-screw Granulation
CHIMIA, 2016 In pharmaceutical manufacturing, there is an increasing interest in continuous manufacturing. As an example for fast continuous processes in general of considerable complexity, this study was focussed on improving the understanding of twin-screw
Adrian Schmidt +4 more
doaj +1 more source
Pharmaceutics, 2022 Twin screw granulation (TSG) is a continuous wet granulation technique that is used widely across different solid manufacturing industries. The TSG has been recognized to have numerous advantages due to its modular design and continuous manufacturing ...
Lalith Kotamarthy +2 more
doaj +1 more source
Conceptualisation of an Efficient Particle-Based Simulation of a Twin-Screw Granulator
Pharmaceutics, 2021 Discrete Element Method (DEM) simulations have the potential to provide particle-scale understanding of twin-screw granulators. This is difficult to obtain experimentally because of the closed, tightly confined geometry.
John P. Morrissey +2 more
doaj +1 more source