Results 31 to 40 of about 19,781 (230)

Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation Development in a Continuous Twin Screw Wet Granulation Process

Pharmaceutics, 2021
The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing. Binder selection for twin-screw wet granulation should rely
Lise Vandevivere, Maxine Vangampelaere, Christoph Portier, Cedrine de Backere, Olaf Häusler, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne   +7 more
doaj   +1 more source

Control oriented modeling of twin-screw granulation in the ConsiGmaTM-25 production plant.

International journal of pharmaceutics, 2023
ConsiGmaTM-25 is a continuous production plant integrating a twin-screw granulation, fluid bed drying, granule conditioning, and a tableting unit. The particle size distribution (PSD), active pharmaceutical ingredient (API) content, and liquid content of
Selma Celikovic, J. Poms, J. Khinast, Martin Horn, J. Rehrl   +4 more
semanticscholar   +1 more source

Parametric Study of Residence Time Distributions and Granulation Kinetics as a Basis for Process Modeling of Twin-Screw Wet Granulation

Pharmaceutics, 2021
Twin-screw wet granulation is a crucial unit operation in shifting from pharmaceutical batch to continuous processes, but granulation kinetics as well as residence times are yet poorly understood.
Timo Plath, Carolin Korte, Rakulan Sivanesapillai, Thomas Weinhart   +3 more
doaj   +1 more source

Asymmetric distribution in twin screw granulation [PDF]

European Journal of Pharmaceutics and Biopharmaceutics, 2016
Positron Emission Particle Tracking (PEPT) was successfully employed to validate measured transverse asymmetry in material distribution in the conveying zones of a Twin Screw Granulator (TSG). Flow asymmetry was established to be a property of the granulator geometry and dependent on fill level. The liquid distribution of granules as a function of fill
Tim, Chan Seem, Neil A, Rowson, Ian, Gabbott, Marcel, de Matas, Gavin K, Reynolds, Andy, Ingram   +5 more
openaire   +2 more sources

Particle-Scale Modeling to Understand Liquid Distribution in Twin-Screw Wet Granulation

Pharmaceutics, 2021
Experimental characterization of solid-liquid mixing for a high shear wet granulation process in a twin-screw granulator (TSG) is very challenging. This is due to the opacity of the multiphase system and high-speed processing.
Ashish Kumar, Stefan Radl, Krist V. Gernaey, Thomas De Beer, Ingmar Nopens   +4 more
doaj   +1 more source

Influence of the Feedstock Preparation on the Properties of Highly Filled Alumina Green-Body and Sintered Parts Produced by Fused Deposition of Ceramic

Ceramics, 2023
This paper investigates new approaches for the blending and plastification of ceramic powder with a binder to form fused deposition of ceramic (FDC) feedstock.
Thomas Heim, Frank Kern
doaj   +1 more source

Sampling and diversion strategy for twin-screw granulation lines using batch statistical process monitoring.

European Journal of Pharmaceutical Sciences, 2022
Continuous manufacturing is now considered as a well-established technique by pharmaceutical companies. However, the limited number of filed applications reflects the complexity to translate a science that has been described in many publications to an ...
F. Stauffer, E. Boulanger, G. Pilcer
semanticscholar   +1 more source

A Population Balance Methodology Incorporating Semi-Mechanistic Residence Time Metrics for Twin Screw Granulation

Processes, 2022
This work is concerned with the incorporation of semi-mechanistic residence time metrics into population balance equations for twin screw granulation processes to predict key properties.
S. Muddu, R. Ramachandran
semanticscholar   +1 more source

Effect of Precirol ATO5 concentration and twin-screw melt granulation temperature on the physical properties of ascorbic acid granules

British Journal of Pharmacy, 2022
The pharmaceutical industry has a growing interest in continuous manufacturing, particularly for high-volume dosage forms such as solid oral tablets. This is driven by the obvious benefits such as small footprint, batch size flexibility, the relative ...
Valentyn Mohylyuk, David Jones, Shu Li, Yalin Ding, Gavin Patrick Andrews   +4 more
doaj   +1 more source

Comparison of Hydroxypropylcellulose and Hot-Melt Extrudable Hypromellose in Twin-Screw Melt Granulation of Metformin Hydrochloride: Effect of Rheological Properties of Polymer on Melt Granulation and Granule Properties

Macromol, 2021
High-molecular-weight hypromellose (HPMC) and hydroxypropyl cellulose (HPC) are widely known, extended-release polymers. Conventional high-molecular-weight HPMCs are preferred in extended-release applications but not widely used in twin-screw melt ...
Amol Batra, Fengyuan Yang, Michael Kogan, Anthony Sosnowik, Courtney Usher, Eugene W. Oldham, Ningyi Chen, Kamaru Lawal, Yunxia Bi, Thomas Dürig   +9 more
doaj   +1 more source