Modelling the Effect of Process Parameters on the Wet Extrusion and Spheronisation of High-Loaded Nicotinamide Pellets Using a Quality by Design Approach [PDF]
, 2019 Open access articleThe aim of the present study was to develop an alternative process to spray granulation in order to prepare high loaded spherical nicotinamide (NAM) pellets by wet extrusion and spheronisation.
Keppler, Julia K +4 more
core +2 more sources
International journal of pharmaceutics, 2020 Due to the numerous advantages over batch manufacturing, continuous manufacturing techniques such as twin screw wet granulation are rapidly gaining importance in pharmaceutical production.
C. Portier +7 more
semanticscholar +1 more source
Continuous twin screw rheo-extrusion of an AZ91D magnesium alloy [PDF]
, 2012 © The Minerals, Metals & Materials Society and ASM International 2012The twin screw rheo-extrusion (TSRE) is designed to take advantage of the nondendritc microstructure and thixotropic characterization of semisolid-metal slurries and produce simple ...
A. Das +34 more
core +1 more source
Continuous direct compression as manufacturing platform for sustained release tablets [PDF]
, 2017 This study presents a framework for process and product development on a continuous direct compression manufacturing platform. A challenging sustained release formulation with high content of a poorly flowing low density drug was selected.
Cunningham, C. +7 more
core +1 more source
A quality by design (QbD) twin—screw extrusion wet granulation approach for processing water insoluble drugs [PDF]
, 2017 In this study, a Quality by Design (QbD) approach was used to identify the effect of formulation parameters in a twin screw wet extrusion granulation process for the manufacturing of ibuprofen (IBU) granules with increased dissolution rates. A fractional
Dey, Tumpa +5 more
core +2 more sources
Development of nutraceutical product [PDF]
, 2015 The aim of this study was to discuss the development of nutraceutical product which includes the current market trends, challenges, and exploitation of natural resources through various processing.
Chin, Nyuk Ling +2 more
core +2 more sources
AAPS PharmSciTechTwin-screw wet granulation (TSWG) is a manufacturing process that offers several advantages for the processing of water-insoluble active pharmaceutical ingredients (APIs) and has been used for increasing the solubility and dissolution rates.
S. Kolipaka +6 more
semanticscholar +1 more source
A novel approach to support formulation design on twin screw wet granulation technology : understanding the impact of overarching excipient properties on drug product quality attributes [PDF]
, 2018 The overall objective of this work is to understand how excipient characteristics influence the drug product quality attributes and process performance of a continuous twin screw wet granulation process.
De Beer, Thomas +5 more
core +2 more sources
International journal of pharmaceutics, 2020 In current study, it was investigated if the moisture-mediated polymorphic transition from δ- to β-mannitol during twin screw granulation (TSG) also took place in high drug loaded formulations and if the specific granule morphology associated with the ...
V. Vanhoorne +3 more
semanticscholar +1 more source
Granule breakage in twin screw granulation: Effect of material properties and screw element geometry [PDF]
Powder Technology, 2017 Abstract This study is the first to explicitly measure the influence of material dynamic yield strength (DYS) and screw element geometry on the breakage process in twin screw granulation. Granule breakage is the key mechanism for controlling granule size within the Twin Screw Granulator.
Shankali U. Pradhan +4 more
openaire +1 more source