Twin Screw Granulation: Effects of Properties of Primary Powders [PDF]
Pharmaceutics, 2018 Lactose and mannitol are some of the most commonly used powders in the pharmaceutical industry. The limited research published so far highlights the effects of process and formulation parameters on the properties of the granules and the tablets produced ...
Sushma V. Lute +2 more
doaj +6 more sources
Twin Screw Granulation: An Investigation of the Effect of Barrel Fill Level [PDF]
Pharmaceutics, 2018 This paper focuses on investigating the influence of varying barrel fill levels on the mean residence time, granule properties (median size, size distribution, and shape), and tensile strength of tablets.
Sushma V. Lute +2 more
doaj +6 more sources
Continuous twin screw granulation: Influence of process variables on granule and tablet quality [PDF]
European Journal of Pharmaceutics and Biopharmaceutics, 2012 The aim of the current study was to screen theophylline (125 mg) tablets manufactured via twin screw granulation in order to improve process understanding and knowledge of process variables that determine granule and tablet quality. A premix of theophylline anhydrate, α-lactose monohydrate and PVP (ratio: 30/67.5/2.5,w/w) was granulated with ...
E Peeters, T de Beer, J P Remon
exaly +6 more sources
Evaluation of Binders in Twin-Screw Wet Granulation [PDF]
Pharmaceutics, 2021 The binders povidone (Kollidon 30), copovidone (Kollidon VA64), hypromellose (Pharmacoat 606), and three types of hyprolose (HPC SSL-SFP, HPC SSL, and HPC SL-FP) were evaluated regarding their suitability in twin-screw wet granulation.
Claudia Köster +2 more
doaj +3 more sources
Effect of Mixing Elements on Granule Formation in Hot Melt Twin Screw Granulation
Chemical Engineering Transactions, 2021 Twin screw granulation (TSG) has been applied to wet granulation, although its application in melt granulation has been more limited. This work explores potential advantages of hot melt granulation using twin screw extrusion.
Nana Sekyi +2 more
doaj +2 more sources
Integrated Continuous Wet Granulation and Drying: Process Evaluation and Comparison with Batch Processing [PDF]
Pharmaceutics, 2023 The pharmaceutical industry is in the midst of a transition from traditional batch processes to continuous manufacturing. However, the challenges in making this transition vary depending on the selected manufacturing process.
Seth P. Forster +4 more
doaj +2 more sources
Investigating the Effects of Mixing Dynamics on Twin-Screw Granule Quality Attributes via the Development of a Physics-Based Process Map [PDF]
PharmaceuticsTwin-screw granulation (TSG) is an emerging continuous wet granulation technique that has not been widely applied in the industry due to a poor mechanistic understanding of the process.
Lalith Kotamarthy +4 more
doaj +2 more sources
Effect of formulation and process variables on lipid based sustained release tablets via continuous twin screw granulation: A comparative study. [PDF]
Eur J Pharm Sci, 2018 &NA; The current study's aim is to prepare lipid based sustained release tablets via a twin‐screw granulation technique and compare those dosage forms with conventional techniques, namely wet granulation and direct compression.
Kallakunta VR +4 more
europepmc +2 more sources
Pharmaceutical Application of Process Understanding and Optimization Techniques: A Review on the Continuous Twin-Screw Wet Granulation [PDF]
Biomedicines, 2023 Twin-screw wet granulation (TSWG) is a method of continuous pharmaceutical manufacturing and a potential alternative method to batch granulation processes.
Jie Zhao, Geng Tian, Haibin Qu
doaj +2 more sources
Application of I-Optimal Design for Modeling and Optimizing the Operational Parameters of Ibuprofen Granules in Continuous Twin-Screw Wet Granulation [PDF]
Biomedicines, 2023 The continuous twin-screw wet granulation (TSWG) process was investigated and optimized with prediction-oriented I-optimal designs. The I-optimal designs can not only obtain a precise estimation of the parameters that describe the effect of five input ...
Jie Zhao, Geng Tian, Haibin Qu
doaj +2 more sources