Results 61 to 70 of about 4,107,894 (287)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Quality-adjusted Time Without Symptoms of disease or Toxicity (Q-TWiST) analysis of CPX-351 versus 7 + 3 in older adults with newly diagnosed high-risk/secondary AML

Journal of Hematology & Oncology, 2021
Background CPX-351 (United States: Vyxeos®; Europe: Vyxeos® Liposomal), a dual-drug liposomal encapsulation of daunorubicin and cytarabine in a synergistic 1:5 molar ratio, is approved by the US FDA and the EMA for the treatment of adults with newly ...
Jorge E. Cortes, Tara L. Lin, Geoffrey L. Uy, Robert J. Ryan, Stefan Faderl, Jeffrey E. Lancet   +5 more
doaj   +1 more source

Nanoparticle-induced twist-grain boundary phase

Physical Review E, 2014
By means of high-resolution ac calorimetry and polarizing optical microscopy, it is demonstrated that surface-functionalized spherical CdSSe nanoparticles induce a twist-grain boundary phase when dispersed in a chiral liquid crystal. These nanoparticles can effectively stabilize the one-dimensional lattice of screw dislocations, thus establishing the ...
Trček, M., Cordoyiannis, G., Tzitzios, V., Kralj, S., Nounesis, G., Lelidis, I., Kutnjak, Z.   +6 more
openaire   +3 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Spin–orbit interactions of twisted random light

APL Photonics
The twist phase of random light represents a nontrivial two-point phase, endowing the field with orbital angular momentum. Although the mutual transition of the spin and orbit angular momenta of coherent light has been revealed, the relationship between ...
Benli Li, Yahong Chen, Weimin Deng, Tongbiao Wang, Lipeng Wan, Tianbao Yu   +5 more
doaj   +1 more source

Are circadian amplitudes and periods correlated? A new twist in the story [version 2; peer review: 3 approved]

F1000Research
Three parameters are important to characterize a circadian and in general any biological clock: period, phase and amplitude. While circadian periods have been shown to correlate with entrainment phases, and clock amplitude influences the phase response ...
Hanspeter Herzel, Christian Gabriel, Achim Kramer, Camillo Mizaikoff, Saskia Grabe, Marta del Olmo, Christoph Schmal   +6 more
doaj   +1 more source

Tunable Electronic Structure in Twisted Bilayer WTe2

Frontiers in Physics, 2022
The moiré pattern restricts the electronic states of transition metal bilayers, thus extending the concept of the magic angle found in twisted bilayer graphene to semiconductors.
Zi-Si Chen, Zi-Si Chen, Lu Huang, Lu Huang, Wen-Ti Guo, Wen-Ti Guo, Kehua Zhong, Kehua Zhong, Jian-Min Zhang, Jian-Min Zhang, Zhigao Huang, Zhigao Huang   +11 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Quality-adjusted Time Without Symptoms or Toxicity (Q-TWiST) for Lenvatinib plus Everolimus Versus Everolimus Monotherapy in Patients with Advanced Renal Cell Carcinoma

European Urology Open Science, 2021
Background: The lenvatinib (LEN) plus everolimus (EVE) combination demonstrated improved progression-free survival over everolimus alone in a phase 2 trial (Study-205).
Chung-Han Lee, Yin Wan, Alan Smith, Ran Xie, Robert J. Motzer   +4 more
doaj   +1 more source

Critical Percolation in the Ordering Kinetics of Twisted Nematic Phases

Physical Review Letters, 2023
I report on the experimental confirmation that critical percolation statistics underlie the ordering kinetics of twisted nematic phases in the Allen-Cahn universality class. Soon after the ordering starts from a homogeneous disordered phase and proceeds towards a broken $\mathbb{Z}_2$-symmetry phase, the system seems to be attracted to the random ...
openaire   +3 more sources