Results 61 to 70 of about 660,441 (286)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Recommendations for choosing an analysis method which controls Type I error for unbalanced cluster sample designs with Gaussian outcomes

Statistics in Medicine, 2015
We used theoretical and simulation‐based approaches to study Type I error rates for one‐stage and two‐stage analytic methods for cluster‐randomized designs.
Jacqueline L Johnson, Sarah M Kreidler, D. Catellier, D. Murray, K. Muller, D. Glueck   +5 more
semanticscholar   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Pro animal-based or pro plant-based? A multi-country consumer segmentation and profiling on willingness to pay for animal- versus plant-based meat and dairy products

Future Foods
A gradual shift from animal-based consumption toward more plant-based diets is crucial for public and planetary health. However, one practical barrier for this protein transition includes the (perceived) financial accessibility of plant-based ...
Rachelle de Vries, Nicole Neufingerl, Elizabeth H. Zandstra   +2 more
doaj   +1 more source

Efficient Preference Clustering via Random Fourier Features

Big Data Mining and Analytics, 2019
Approximations based on random Fourier features have recently emerged as an efficient and elegant method for designing large-scale machine learning tasks.
Jingshu Liu, Li Wang, Jinglei Liu
doaj   +1 more source

Two stage adaptive cluster sampling based on ordered statistics

Advances in Methodology and Statistics, 2019
The estimation problem on sparsely distributed populations using adaptive cluster sampling (ACS) is discussed. In the first phase of ACS, two stage sampling is used in which primary and secondary sampling units are selected using simple random sampling without replacement.
Girish Chandra, Neeraj Tiwari, Raman Nautiyal   +2 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Could the clinical interpretability of subgroups detected using clustering methods be improved by using a novel two-stage approach?

Chiropractic & Manual Therapies, 2015
BackgroundRecognition of homogeneous subgroups of patients can usefully improve prediction of their outcomes and the targeting of treatment. There are a number of research approaches that have been used to recognise homogeneity in such subgroups and to ...
P. Kent, M. Stochkendahl, H. W. Christensen, A. Kongsted   +3 more
semanticscholar   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source