Results 81 to 90 of about 660,441 (286)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Developing and validating a media health literacy scale with a critical approach for high school students in Tehran

Payesh, 2021
Objective(s): Every society has a level of media literacy, but what is important is a critical approach to media content, which is of particular importance among adolescents and young people.
abolghasem raeisi nafchi, abolfazl danaei, Seyed Mohammad Zargar   +2 more
doaj  

GENERALISED MODEL BASED CONFIDENCE INTERVALS IN TWO STAGE CLUSTER SAMPLING

Pakistan Journal of Statistics and Operation Research, 2010
Chambers and Dorfman (2002) constructed bootstrap confidence intervals in model based estimation for finite population totals assuming that auxiliary values are available throughout a target population and that the auxiliary values are independent. They also assumed that the cluster sizes are known throughout the target population. We now extend to two
Christopher Ouma Onyango, Romanus Odhiambo Otieno, George Otieno Orwa   +2 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Trends in HIV-related knowledge, behaviors and determinants of HIV testing among adolescent women aged 15–24 in Nigeria

Tropical Medicine and Health
Background HIV remains one of the major global public health challenges, having claimed over 36 million lives so far, especially in sub-Saharan African countries like Nigeria.
Okoro Lenz Nwachinemere, Simon Nyegenye, Aaron Mwesigwa, Naya Gadzama Bulus, Jonathan Mawutor Gmanyami, Kaweesi Abdulrahim Mukisa, Isaac Isiko   +6 more
doaj   +1 more source

Estimating the Population Mean in Two-Stage Sampling with Equal Size Clusters under Non-Response Using Auxiliary Characteristic

, 2013
The present paper has been devoted to the study of estimating the population mean in two-stage sampling with equal size clusters under non-response using an auxiliary variable. This paper focuses on the study of general families of factor-type estimators
M. K. Chaudhary, V. Singh
semanticscholar   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Life Stage Identification of Space Rolling Bearings Based on Class-contrast Cluster-allocation Heterogeneous Transfer Learning

工程科学与技术
Life stage identification accuracy of space rolling bearings is low due to the large difference of sample distribution, the small number of available training samples, and the unequal number of samples at different life stages under variable working ...
Fengliang LIU, Feng LI, Baoping TANG, Yongchao WANG, Daqing TIAN   +4 more
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source