Results 41 to 50 of about 160,344 (293)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Estimation of finite population mean in a complex survey sampling.

PLoS ONE
Accurate estimation of the finite population mean is a fundamental challenge in survey sampling, especially when dealing with large or complex populations.
Mohsin Abbas, Muhammad Ahmed Shehzad, Mahwish Rabia, Haris Khurram, Muhammad Ijaz   +4 more
doaj   +1 more source

Lifetime and past-year suicidal behaviors among adolescents in Bangladesh: A two-stage stratified cluster sampling study

Cambridge Prisms: Global Mental Health
Adolescence is a critical period marked by significant physical and psychological changes, yet there is limited understanding of suicidal behaviors among adolescents in Bangladesh.
Firoj Al-Mamun, Abdullah Al Habib, Johurul Islam, Moneerah Mohammad ALmerab, Mohammed A. Mamun, Mohammad Muhit   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Imbalanced data ensemble classification based on cluster-based under-sampling algorithm

工程科学学报, 2017
Most traditional classification algorithms assume the data set to be well-balanced and focus on achieving overall classification accuracy. However, actual data sets are usually imbalanced, so traditional classification approaches may lead to ...
WU Sen, LIU Lu, LU Dan
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Single-stage cluster sampling.

, 2015
Quantile boxplots for 1,000 stratified 4-level simulated single-stage cluster sampling trials using H-T estimation. The bar in each box is the median value of the estimate, while outliers deviating by one or more quantiles from the median are denoted as ...
Rashid Ansumana (586899), Kathryn H. Jacobsen (661129), Joseph M. Lamin (661132), Alfred S. Bockarie (661130), Umaru Bangura (661131), Joel D. Alejandre (661128), Roger Hillson (661127), David A. Stenger (25896)   +7 more
core   +1 more source

Consumer Preferences of the Surabaya Community towards MP-ASI Premixed Rice

Jurnal Pangan dan Agroindustri
Surabaya is one of the places for producers who provide MP-ASI products with various attributes, one of these products is MP-ASI premixed rice. This study aims to find out some of the attributes with the highest importance value for consumers in choosing
Mochamad Harits Pradana Misbach, Ratna Yulistiani, Anugerah Dany Priyanto, Awanda Winar Fitriani   +3 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source