Results 51 to 60 of about 1,014,329 (297)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Least Squares Based and Two-Stage Least Squares Based Iterative Estimation Algorithms for H-FIR-MA Systems [PDF]
Mathematical Problems in Engineering, 2015 This paper studies the identification of Hammerstein finite impulse response moving average (H-FIR-MA for short) systems. A new two-stage least squares iterative algorithm is developed to identify the parameters of the H-FIR-MA systems. The simulation cases indicate the efficiency of the proposed algorithms.
Zhenwei Shi, Zhicheng Ji
openaire +2 more sources
Journal of Econometrics, 2019 General parametric forms are assumed for the conditional mean λ_{t}(θ₀) and variance υ_{t}(ξ₀) of a time series. These conditional moments can for instance be derived from count time series, Autoregressive Conditional Duration (ACD) or Generalized ...
A. Aknouche, C. Francq
semanticscholar +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Characterization of the asymptotic distribution of semiparametric M-estimators [PDF]
, 2010 This paper develops a concrete formula for the asymptotic distribution of two-step, possibly non-smooth semiparametric M-estimators under general misspecification.
Ichimura, H, Lee, S
core +3 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
, 2008 Let $\mathbf{Y}=\mathbf{X}\bolds{\Theta}\mathbf{Z}'+\bolds{\mathcal {E}}$ be the growth curve model with $\bolds{\mathcal{E}}$ distributed with mean $\mathbf{0}$ and covariance $\mathbf{I}_n\otimes\bolds{\Sigma}$, where $\bolds{\Theta}$, $\bolds{\Sigma}$
Hu, Jianhua, Yan, Guohua
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Applied Sciences, 2020 This study focuses on identifying personality traits in computer science students and determining whether they are related to academic performance. In addition, the importance of the personality traits based on motivation scale and depression, anxiety ...
Hanns de la Fuente-Mella +10 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source