Results 81 to 90 of about 1,008,660 (269)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A Multi-Step Sequential System Optimization Design Method for Upper Stages

Journal of Aerospace Technology and Management, 2023
This paper proposes a new approach in multi-step sequential system optimization (MSSO) to implement a conceptual design for satellite upper stage with a maneuver in the conditions close to reality.
Vahid Bohlouri, Mostafa Zakeri, Mehran Nosratollahi   +2 more
doaj  

On Artificial-Noise Aided Transmit Design for Multi-User MISO Systems with Integrated Services

, 2017
This paper considers artificial noise (AN)-aided transmit designs for multi-user MISO systems in the eyes of service integration. Specifically, we combine two sorts of services, and serve them simultaneously: one multicast message intended for all ...
Chen, Zhi, Fang, Jun, Li, Lingxiang, Li, Shaoqian, Mei, Weidong   +4 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A Two‐Stage Energy‐Efficiency Optimization Approach for Conflict‐Free Dispatching in Open‐Pit Mines

IET Intelligent Transport Systems
The objective of this paper is to present a novel energy‐efficiency conflict‐free dispatching algorithm for autonomous mining fleets. In lieu of halting or decelerating the trucks at intersections when conflicts arise, the algorithm facilitates conflict ...
Zhichao Wang, Jue Yang, Yanbiao Feng, Yiting Kang, Yong Li   +4 more
doaj   +1 more source

Hybrid GA-SOCP Approach for Placement and Sizing of Distributed Generators in DC Networks

Applied Sciences, 2020
This research addresses the problem of the optimal location and sizing distributed generators (DGs) in direct current (DC) distribution networks from the combinatorial optimization.
Oscar Danilo Montoya, Walter Gil-González, Luis Fernando Grisales-Noreña   +2 more
doaj   +1 more source

OPTIMAL, TWO STAGE, ADAPTIVE ENRICHMENT DESIGNS FOR RANDOMIZED TRIALS USING SPARSE LINEAR PROGRAMMING [PDF]

, 2017
Adaptive enrichment designs involve preplanned rules for modifying enrollment criteria based on accruing data in a randomized trial. We focus on designs where the overall population is partitioned into two predefined subpopulations, e.g., based on a ...
Fang, Xingyuan, Liu, Han, Rosenblum, Michael   +2 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Efficient Motion Planning Algorithm for Stochastic Dynamic Systems with Constraints on Probability of Failure [PDF]

, 2008
When controlling dynamic systems such as mobile robots in uncertain environments, there is a trade off between risk and reward. For example, a race car can turn a corner faster by taking a more challenging path.
Ono, Masahiro, Williams, Brian C.
core   +2 more sources