Structural biology of ferritin nanocages
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
A Multiperiod OPF Model Under Renewable Generation Uncertainty and Demand Side Flexibility
Renewable energy sources such as wind and solar have received much attention in recent years and large amount of renewable generation is being integrated to the electricity networks.
Bukhsh, W. A., Pinson, P., Zhang, C.
core +1 more source
On the Regularized Decomposition Method for Two Stage Stochastic Linear Problems [PDF]
A new approach to the regularized decomposition (RD) algorithm for two stage stochastic problems is presented. The RD method combines the ideas of the Dantzig-Wolfe decomposition principle and modern nonsmooth optimization methods.
Ruszczynski, A., Swietanowski, A.
core +1 more source
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
A Two-Stage Stochastic Programming Approach for Energy-Oriented Lot-Sizing
We consider an industrial plant equipped with an on-sitepower generation system based on intermittent renewable energy. Weinvestigate the problem of simultaneously planning the industrial productionand the energy supply in this plant on a short-therm horizon.We propose to handle the resulting energy-oriented lot-sizing problem bya two-stage scenario ...
Liao, Ruiwen +3 more
openaire +2 more sources
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
On the Dynamic Programming approach to economic models governed by DDE's [PDF]
In this paper a family of optimal control problems for economic models is considered, whose state variables are driven by Delay Differential Equations (DDE's).
Fabbri, Giorgio +2 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A novel scenario planning approach considering criteria interaction in multi-criteria evaluation: An application to urban mobility [PDF]
This study proposes a new scenario planning approach which consists of two main stages: evaluating scenarios under multiple criteria and selecting a manageable number of representative scenarios covering a wide range of future developments.
Ozgur Yanmaz, Umut Asan
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source

