Results 1 to 10 of about 32,448 (172)

Engineering and Evaluation of a Live-Attenuated Vaccine Candidate with Enhanced Type 1 Fimbriae Expression to Optimize Protection Against Salmonella Typhimurium [PDF]

Vaccines
Background:Salmonella Typhimurium is a major zoonotic pathogen, in which type 1 fimbriae play a crucial role in intestinal colonization and immune modulation.
Patricia García, Arianna Rodríguez-Coello, Andrea García-Pose, María Del Carmen Fernández-López, Andrea Muras, Miriam Moscoso, Alejandro Beceiro, Germán Bou   +7 more
doaj   +4 more sources

What Flips the Switch? Signals and Stress Regulating Extraintestinal Pathogenic Escherichia coli Type 1 Fimbriae (Pili) [PDF]

Microorganisms, 2021
Pathogens are exposed to a multitude of harmful conditions imposed by the environment of the host. Bacterial responses against these stresses are pivotal for successful host colonization and pathogenesis. In the case of many E.
Hicham Bessaiah, Carole Anamalé, Jacqueline Sung, Charles M. Dozois   +3 more
doaj   +2 more sources

Role of type 1 and type 3 fimbriae in Klebsiella pneumoniae biofilm formation [PDF]

BMC Microbiology, 2010
Background Klebsiella pneumoniae is an important gram-negative opportunistic pathogen causing primarily urinary tract infections, respiratory infections, and bacteraemia. The ability of bacteria to form biofilms on medical devices, e.g.
Krogfelt Karen A, Barken Kim B, Schroll Casper, Struve Carsten   +3 more
doaj   +6 more sources

Fimbriae reprogram host gene expression - Divergent effects of P and type 1 fimbriae. [PDF]

PLoS Pathogens, 2019
Pathogens rely on a complex virulence gene repertoire to successfully attack their hosts. We were therefore surprised to find that a single fimbrial gene reconstitution can return the virulence-attenuated commensal strain Escherichia coli 83972 to ...
Ines Ambite, Daniel S C Butler, Christoph Stork, Jenny Grönberg-Hernández, Bela Köves, Jaroslaw Zdziarski, Jerome Pinkner, Scott J Hultgren, Ulrich Dobrindt, Björn Wullt, Catharina Svanborg   +10 more
doaj   +2 more sources

yqhG Contributes to Oxidative Stress Resistance and Virulence of Uropathogenic Escherichia coli and Identification of Other Genes Altering Expression of Type 1 Fimbriae [PDF]

Frontiers in Cellular and Infection Microbiology, 2019
Urinary tract infections (UTIs) are common bacterial infections and the vast majority of UTIs are caused by extraintestinal pathogenic Escherichia coli (ExPEC) strains referred to as uropathogenic E. coli (UPEC).
Hicham Bessaiah, Hicham Bessaiah, Pravil Pokharel, Pravil Pokharel, Hajer Habouria, Hajer Habouria, Sébastien Houle, Sébastien Houle, Charles M. Dozois, Charles M. Dozois   +9 more
doaj   +2 more sources

Surface Display of Type 1 Fimbriae on Shigella flexneri Induces Antigen-Specific Immune Response via Oral Route [PDF]

Vaccines
Background: Live attenuated bacteria are promising candidates for mucosal vaccine delivery due to their ability to elicit robust immune responses. FimH is the adhesion protein of type 1 fimbriae, which is used as mucosal adjuvants.
Shuli Sang, Rui Yu, Yunyun Mao, Yanfang Zhai, Chen Cao, Kai Li, Yiyan Guan, Haoxia Tao, Chunjie Liu, Yanchun Wang   +9 more
doaj   +2 more sources

Adhesion of Escherichia Coli to Nanostructured Surfaces and the Role of Type 1 Fimbriae [PDF]

Nanomaterials, 2020
Bacterial fimbriae are an important virulence factor mediating adhesion to both biotic and abiotic surfaces and facilitating biofilm formation. The expression of type 1 fimbriae of Escherichia coli is a key virulence factor for urinary tract infections ...
Pawel Kallas, Håvard J Haugen, Nikolaj Gadegaard, John Stormonth-Darling, Mats Hulander, Martin Andersson, Håkon Valen   +6 more
doaj   +2 more sources

The osmoregulated metabolism of trehalose contributes to production of type 1 fimbriae and bladder colonization by extraintestinal Escherichia coli strain BEN2908 [PDF]

Frontiers in Cellular and Infection Microbiology
In Escherichia coli, the disaccharide trehalose can be metabolized as a carbon source or be accumulated as an osmoprotectant under osmotic stress. In hypertonic environments, E. coli accumulates trehalose in the cell by synthesis from glucose mediated by
Vivian Souza Klemberg, Vivian Souza Klemberg, Daniel Brisotto Pavanelo, Sébastien Houle, Sabin Dhakal, Pravil Pokharel, Simone Iahnig-Jacques, Charles M. Dozois, Fabiana Horn   +8 more
doaj   +2 more sources

Identification of OxyR as an activator of type 1 fimbriae (fim) in Salmonella enterica serovar Typhi [PDF]

Microbiology Spectrum
Salmonella enterica serovar Typhi (S. Typhi) encodes 14 fimbrial gene clusters, including the mannose-binding type 1 fimbriae known as Fim. Type 1 fimbriae have been implicated in biofilm formation and adhesion to host cells in Salmonella. However, their
Karine Dufresne, Camille Ou, Melvina Badet, Gabrielle Cadieux, France Daigle   +4 more
doaj   +2 more sources

Type 1 fimbriae-mediated collective protection against type 6 secretion system attacks [PDF]

mBio
Bacterial competition may rely on secretion systems such as the type 6 secretion system (T6SS), which punctures and releases toxic molecules into neighboring cells.
Margot Marie Dessartine, Artemis Kosta, Thierry Doan, Éric Cascales, Jean-Philippe Côté   +4 more
doaj   +2 more sources