Results 101 to 110 of about 1,499,825 (316)

Contemporary risk of hip fracture in type 1 and type 2 diabetes:a national registry study from Scotland [PDF]

, 2014
The purpose of this study was to compare contemporary risk of hip fracture in type 1 and type 2 diabetes with the nondiabetic population. Using a national diabetes database, we identified those with type 1 and type 2 diabetes who were aged 20 to 84 years
McKnight, John, Looker, Helen C., Leese, Graham P., Livingstone, Shona J., Wild, Sarah H., Ahmed, S. Faisal, Philip, Sam, Wild, Sarah H.; id_orcid, Hothersall, Eleanor J., Cleland, Steve, Lindsay, Robert S., Cleland, Steve., Pearson, Donald, Colhoun, Helen M.   +13 more
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

The inflammation, vascular repair and injury responses to exercise in fit males with and without Type 1 diabetes: an observational study [PDF]

, 2015
Background: Type 1 diabetes is associated with raised inflammation, impaired endothelial progenitor cell mobilisation and increased markers of vascular injury. Both acute and chronic exercise is known to influence these markers in non diabetic controls,
Wijaya, Stephanie, Gonzalez, JT, Walker, Mark, Emma J Stevenson, Gonzalez, Javier T, Wijaya, S, Gonzalez, Javier T., West, Daniel J., West, Daniel J, Walker, M, Mark Walker, Fahad W Ahmed, Weaver, JU, Stevenson, Emma J., Gonzalez, Javier, West, DJ, Campbell, MD, Shaw, James A, Daniel J West, Ahmed, Fahad W., Stevenson, Emma, Campbell, Matthew, Weaver, Jolanta U., Jolanta U Weaver, Ahmed, Fahad, Shaw, James, Stephanie Wijaya, Shaw, JA, Campbell, Matthew D., Javier T Gonzalez, James A Shaw, Ahmed, Fahad W, Shaw, James A., Matthew D Campbell, Stevenson, Emma J, Weaver, Jolanta U, Stevenson, EJ, Weaver, Jolanta, Ahmed, FW, West, Dan   +39 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

TMEM219 regulates the transcription factor expression and proliferation of beta cells

Frontiers in Endocrinology
Pancreatic beta cells replenishment is considered the next therapeutic option for type 1 diabetes; while stimulating endogenous beta cells proliferation is the “holy grail” for those patients with exhausted beta cell mass.
Francesca D’Addio, Francesca D’Addio, Emma Assi, Anna Maestroni, Giada Rossi, Vera Usuelli, Adriana Petrazzuolo, Marta Nardini, Marta Nardini, Cristian Loretelli, Moufida Ben Nasr, Moufida Ben Nasr, Paolo Fiorina, Paolo Fiorina, Paolo Fiorina   +14 more
doaj   +1 more source

The emerging role of targeting cancer metabolism for cancer therapy

Tumor Biology, 2020
Glucose, as the main consuming nutrient of the body, faces different destinies in cancer cells. Glycolysis, oxidative phosphorylation, and pentose phosphate pathways produce different glucose-derived metabolites and thus affect cells’ bioenergetics ...
Pegah Farhadi, Reza Yarani, Sadat Dokaneheifard, Kamran Mansouri   +3 more
doaj   +1 more source

The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy [PDF]

, 2014
The discovery of increased formation of methylglyoxal (MG) by cell metabolism in high glucose concentration in vitro suggested possible relevance to diabetes and diabetes complications (1,2).
Rabbani, Naila, Thornalley, Paul J.
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source