Results 101 to 110 of about 2,364,373 (300)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Acute hypoglycemia impairs executive cognitive function in adults with and without type 1 diabetes [PDF]

, 2013
OBJECTIVE: Acute hypoglycemia impairs cognitive function in several domains. Executive cognitive function governs organization of thoughts, prioritization of tasks, and time management.
A. J. Graveling, Albinet, B. M. Frier, Berg, Cox, Elliott, Evans, Geddes, Goel, Gold, Gold, Hardy, Heller, Homack, I. J. Deary, Kerr, Maran, Pedersen-Bjergaard, Salthouse, Sommerfield, Sommerfield, Van der Elst, Warren   +22 more
core   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Obesity and diabetes in New Zealand [PDF]

Obesity is a risk factor for diabetes, cardiovascular disease, musculoskeletal disorders, and some cancers. Introduction It is estimated that 1.1 million adults are obese in New Zealand (that is, they have a BMI or Body Mass Index of 30 or more ...
Alexandra Marett
core  

Long-term Glycemic Control and Dementia Risk in Type 1 Diabetes. [PDF]

, 2018
ObjectiveIndividuals with type 1 diabetes have experienced an increase in life expectancy, yet it is unknown what level of glycemic control is ideal for maintaining late-life brain health.
Gilsanz, Paola, Karter, Andrew J, Lacy, Mary E, Pletcher, Mark J, Quesenberry, Charles P, Whitmer, Rachel A   +5 more
core  

Diabetes and pregnancy:national trends over a 15 year period [PDF]

, 2018
Aims/hypothesis: We aimed to examine time trends in national perinatal outcomes in pregnancies complicated by pre-existing type 1 or type 2 diabetes. Methods: We analysed episode-level data on all obstetric inpatient delivery events (live or stillbirth ...
BE Metzger, D Kernaghan, F Johnstone, GC Penney, GC Penney, Graham P. Leese, H Anwar, H Fadl, Helen M. Colhoun, HR Murphy, HW Valk de, IM Evers, JA Mcknight, Joannes J. Kerssens, M Perrson, M Persson, M Persson, MCM Macintosh, P Boulot, P Ekbom, Rachael Wood, RC Temple, Robert S. Lindsay, S Bonellie, S Campbell, Sam Philip, Sarah Wild, Scott M. Nelson, SH Read, Sharon T. Mackin, SJ Livingstone   +30 more
core   +6 more sources

Type 1 Diabetes [PDF]

, 2007
It is well known that type 1 diabetes is a chronic autoimmune disease in which the breakdown of normal tolerance to the cell allows the activation of T cell to multiple antigens. This induces a progressive destruction of cells and a state of chronic insulin deficiency.
Francesco Chiarelli, Cosimo Giannini
openaire   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

Preventing the onset of diabetes with precision delivery of mesenchymal stem cells to the pancreas in a preclinical model

Stem Cell Research & Therapy
Background Mesenchymal stem cells (MSCs) represent a promising regenerative therapy associated with anti-inflammatory, anti-apoptotic, and pro-proliferative properties.
Reza Yarani, Rosita Primavera, Shashank Chetty, Jing Wang, Simranjeet Kaur, Martin Haupt-Jorgensen, Flemming Pociot, Avnesh S. Thakor   +7 more
doaj   +1 more source