Results 91 to 100 of about 36,666,975 (299)

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

Etiology of Type 1 Diabetes [PDF]

Immunity, 2010
Recent genetic mapping and gene-phenotype studies have revealed the genetic architecture of type 1 diabetes. At least ten genes so far can be singled out as strong causal candidates. The known functions of these genes indicate the primary etiological pathways of this disease, including HLA class II and I molecules binding to preproinsulin peptides and ...
openaire   +2 more sources

Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth [PDF]

, 2009
OBJECTIVE: Low birth weight is associated with an increased risk of type 2 diabetes. The mechanisms underlying this association are unknown and may represent intrauterine programming or two phenotypes of one genotype.
Timpson, NJ, Ruokonen, A, Weedon, Michael N, Hattersley, AT, McCarthy, MI, Pouta, Anneli, Lindgren, Cecilia M, Perry, JR, Weedon, MN, Elliott, P, Groves, Christopher J, Smith, GD, Shields, B, Power, C, Järvelin, MR, Hyppönen, E, Shields, Beverley, Zeggini, Eleftheria, McCarthy, Mark I, Bennett, Amanda J, Ring, Susan M, Power, Chris, Ring, SM, Ruokonen, Aimo, Pouta, A, Strachan, DP, Elliott, Paul, Järvelin, Marjo-Riitta, Timpson, Nicholas J, Lango, Hana, Groves, CJ, Bennett, AJ, Hattersley, Andrew T, Lindgren, CM, Smith, George Davey, Zeggini, E, Frayling, Timothy M, Strachan, David P, Lango, H, Hyppönen, Elina, Freathy, RM, Perry, John R B, Frayling, TM, Freathy, Rachel M, Freathy, R.M., Hypponen, E., Hattersley, A.T., Shields, B., Ring, S.M., Bennett, A.J.   +49 more
core   +1 more source

The emerging role of targeting cancer metabolism for cancer therapy

Tumor Biology, 2020
Glucose, as the main consuming nutrient of the body, faces different destinies in cancer cells. Glycolysis, oxidative phosphorylation, and pentose phosphate pathways produce different glucose-derived metabolites and thus affect cells’ bioenergetics ...
Pegah Farhadi, Reza Yarani, Sadat Dokaneheifard, Kamran Mansouri   +3 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

A study of diabetes mellitus within a large sample of Australian twins. [PDF]

, 2008
Udgivelsesdato: 2008-FebTwin studies of diabetes mellitus can help elucidate genetic and environmental factors in etiology and can provide valuable biological samples for testing functional hypotheses, for example using expression and methylation studies
Kyvik, Kirsten O; id_orcid, Condon, Julianne, Luciano, Michelle, Kyvik, Kirsten O, Duffy, David L, Shaw, Joanne E, Martin, Nicholas G   +6 more
core   +1 more source

A study to determine a capillary alternative to the gold standard oral glucose tolerance test - Protocol [version 2; peer review: 1 approved, 2 approved with reservations]

Wellcome Open Research
Type 1 diabetes (T1D) is a chronic condition caused by the immune destruction of the pancreatic beta cells. T1D has recognised asymptomatic pre-clinical stages, providing an opportunity for early diagnosis, education and treatment which may delay the ...
Gareth Dunseath, John A Todd, Colin Dayan, Steve Luzio, Rachel E J Besser, M. Loredana Marcovecchio, Rabbi Swaby, Tabitha Randell, Claire Scudder, Yuk-Fun Liu, Kathleen Gillespie   +10 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Network-Level Structural Abnormalities of Cerebral Cortex in Type 1 Diabetes Mellitus [PDF]

, 2013
Type 1 diabetes mellitus (T1DM) usually begins in childhood and adolescence and causes lifelong damage to several major organs including the brain. Despite increasing evidence of T1DM-induced structural deficits in cortical regions implicated in higher ...
Hyeonseok S Jeong, Gail Musen, Hyeonseok S. Jeong (449823), In Kyoon Lyoo (399200), Weinger, K, Weinger Katie, Sujin Bae (279960), Jiyoung J. Jung (399196), Bolo, Nicolas, Bae, Sujin, Donald C. Simonson (297772), Bae, S, Lyoo In Kyoon, Lyoo, In Kyoon, Gail Musen (449820), Nicolas Bolo, Yoon, Sujung, Yera Choi (399197), Lyoo, IK, Jacobson, Alan M., Jieun E. Kim (449821), Ryan, CM, Simonson, Donald, Sujin Bae, Sujung Yoon (399194), Katie Weinger, Jeong Hyeonseok S., Simonson, Donald C., Christopher M. Ryan (410965), Hwang, J, Choi, Yera, Zuo, Xi-Nian, Kim Jieun E., Sujung Yoon, Bae Sujin, Bolo, N, Alan M Jacobson, Alan M. Jacobson (399199), Jeong, Hyeonseok S., Renshaw, PF, Jeong, HS, Sun Hea Lee (449824), Musen, G, Hwang Jaeuk, Simonson Donald C., Lee Sun Hea, Jacobson, AM, Lee, Sun Hea, Yera Choi, Perry F Renshaw, Ryan, Christopher M., Christopher M Ryan, Jung, JJ, Musen Gail, Jung Jiyoung J., In Kyoon Lyoo, Perry F. Renshaw (286262), Choi, Y, Renshaw, Perry F., Jiyoung J Jung, Hwang, Jaeuk, Kim, Jieun E., Yoon Sujung, Lee, SH, Jung, Jiyoung J., Weinger, Katie, Yoon, S, Kim, JE, Katie Weinger (449825), Choi Yera, Renshaw Perry F., Ryan Christopher M., Jacobson Alan M., Musen, Gail, Jaeuk Hwang, Donald C Simonson, Sun Hea Lee, Bolo Nicolas, Jieun E Kim, Jaeuk Hwang (449819), Nicolas Bolo (449822), Simonson, DC   +81 more
core   +2 more sources

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source