Results 91 to 100 of about 1,499,825 (316)

The genetics of type 1 diabetes: family and population studies [PDF]

, 1994
Type 1 (insulin-dependent) diabetes mellitus is caused by autoimmune destruction of insulin-producing pancreatic ß-cells. Genetic susceptibility is necessary for the development of type 1 diabetes but inheritance does not follow simple Mendelian rules ...
Bain, Stephen Charles
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The Discovery of Type 1 Diabetes [PDF]

Diabetes, 2001
The etiological heterogeneity of idiopathic diabetes has been recognized for 25 years, and subdivision into type 1 and type 2 diabetes is fundamental to the way we think about the disease. Review of the literature suggests that the concept of type 1 diabetes as an immunemediated disease emerged rapidly over the period from 1974 to 1976 and showed many ...
openaire   +2 more sources

Preconception counselling in women with diabetes: a population-based study in the North of England [PDF]

, 2009
To investigate the association of preconception counseling with markers of care and maternal characteristics in women with pregestational diabetes. The study includes data from a regional multi-center survey on 588 women with pregestational diabetes who ...
Chandler, Colin, Bell, Ruth, Tripathi, Anvish, Aarvold, Joan, Chandler, Colin; id_orcid, Rankin, Judith, Tripathi, Avnish   +6 more
core   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Addressing the educational and psychosocial issues in type 1 diabetes [PDF]

, 2010
People with type 1 diabetes require good self-management skills in order to achieve good levels of diabetes control. Self-management skills can be onerous and can cause significant disruption to people's lives.
Naik, Sarita
core  

Association of N-terminal pro-brain natriuretic peptide with cognitive function and depression in elderly people with type 2 diabetes [PDF]

, 2012
<p>Background: Type 2 diabetes mellitus is associated with risk of congestive heart failure (CHF), cognitive dysfunction and depression. CHF itself is linked both to poor cognition and depression.
Deary, Ian J., Rebecca M Reynolds, Ian J Deary, Price Jackie F., Welsh, Paul, Reynolds, Rebecca M., Mark W J Strachan, Sattar Naveed, Welsh Paul, Paul Welsh, Feinkohl, Insa, Price, Jackie F.; id_orcid, Reynolds Rebecca M., Strachan Mark W. J., Price, Jackie F., Strachan, Mark W.J., Sattar, Naveed, Deary, Ian, Edinburgh Type 2 Diabetes Study-ET2DS Investigators, Deary Ian J., ?, ?, Strachan, Mark W. J., Naveed Sattar, Jackie F Price, Feinkohl Insa, Insa Feinkohl   +25 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Sex-specific-differences in cardiovascular risk in type-1-diabetes : a cross sectional study [PDF]

, 2013
Background: Little is known about the impact of sex-specific differences in the management of type 1 diabetes (T1DM). Thus, we evaluated the influence of gender on risk factors, complications, clinical care and adherence in patients with T1DM.
Kautzky, Alexander, Saukel, Johannes (Department of Pharmacognosy, Faculty of Life Sciences, University of Vienna), Stich, Kathrin (Department of Pharmacology and Toxicology, Faculty of Life Sciences, University of Vienna), Alexander Kautzky, Kautzky, Alexander (Gender Medicine Unit, Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna), Hintersteiner, Juliane (Department of Pharmacology and Toxicology, Faculty of Life Sciences, University of Vienna), Kautzky-Willer, Alexandra (Gender Medicine Unit, Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna), Johannes Saukel, Kautzky-Willer, Alexandra, Stich, Kathrin, Lemmens-Gruber, Rosa, Lemmens-Gruber, Rosa (Department of Pharmacology and Toxicology, Faculty of Life Sciences, University of Vienna), Saukel, Johannes, Majid Kamyar, Johnson, Julienne, Juliane Hintersteiner, Hinstersteiner, Juliane, Kamyar, Majid (Department of Pharmacology and Toxicology, Faculty of Life Sciences, University of Vienna), Alexandra Kautzky-Willer, Kathrin Stich, Johnson, Julienne (Strathclyde Institute of Pharmacy and Biomedical Sciences, Strathclyde University), Kamyar, Majid Reza, Julienne Johnson, Rosa Lemmens-Gruber   +23 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source