Results 81 to 90 of about 36,666,975 (299)

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Incidence of type 1 diabetes in Australia 2000–2013 [PDF]

, 2015
Presents the latest available national data on new cases of type 1 diabetes from Australia’s National (insulin-treated) Diabetes Register. In 2013, there were 2,323 new cases of type 1 diabetes in Australia, equating to 11 cases per 100,000 population ...
Australian Institute of Health and Welfare
core  

Serum levels of advanced glycation endproducts and other markers of protein damage in early diabetic nephropathy in type 1 diabetes [PDF]

, 2012
Objective To determine the role of markers of plasma protein damage by glycation, oxidation and nitration in microalbuminuria onset or subsequent decline of glomerular filtration rate (termed “early GFR decline”) in patients with type 1 diabetes ...
Weston Andrew, Rabbani, N, Warram, James, Paul Thornalley, Perkins, BA, Naila Rabbani, Monika Niewczas, Thornalley, P, Thornalley, Paul J., Krolewski, AS, Rabbani, Naila, Adaikalakoteswari Antonysunil, Perkins Bruce A., Bruce A Perkins, Perkins, Bruce A., Weston, A, Thornalley Paul, Rabbani Naila, Krolewski, Andrzej S., Niewczas, M, Antonysunil Adaikalakoteswari, Adaikalakoteswari, A, Weston, Andrew J., Linda H Ficociello, Ficociello, LH, Ficociello Linda H., James Warram, Andrzej S Krolewski, Niewczas Monika, Warram, J, Andrew Weston, Antonysunil, Adaikalakoteswari, Warram James, Krolewski Andrzej S., Niewczas, Monika, Ficociello, Linda H.   +35 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes:rationale and design of the epidemiological studies within the IMI DIRECT Consortium [PDF]

, 2014
Aims/hypothesisThe DIRECT (Diabetes Research on Patient Stratification) Study is part of a European Union Framework 7 Innovative Medicines Initiative project, a joint undertaking between four industry and 21 academic partners throughout Europe.
Rauh, S., Jablonka, B, Bernd Jablonka, Teare, Harriet J A, Frost, G.S., Ridderstråle, Martin, Herrgard, S., Hattersley, A, McDonald, T. J., Sanna Herrgård, Franks, Paul W., Bell, J., Cederberg, Henna, Hansen, TH, Andrea Mari, Pedersen, Oluf, Siloaho, Maritta, Mark Walker, Pearson, Ewan; id_orcid, Pearson, Ewan, Heymans, Martijn W., Perry, MH, Hansen, T.H., Rauh, S, Veikko Koivisto, Ridderstråle, Martin,, McDonald, T.J., Brunak, Søren, Cederberg, H., Barnett, A, Heymans, MartijnW., Frost, G, Vestergaard, H., Hattersley, Andrew T., Franks, P.W., Perry, Mandy, Laakso, M., Consortium, Direct, Paul W. Franks, Barnett, A., Heggie, A., Hansen, T., Thorand, Barbara, Heymans, MW, Siloaho, M., null null, Maritta Siloaho, Koivula, RW, Henrik Vestergaard, Hansen, Tue H., Alison Heggie, Lund University., Teare, Harriet J. A., Hansen, Tue H, Ewan Pearson, Ruetten, H, Hansen, T, Ramneek Gupta, Dekker, Jacqueline M, Rutters, Femke, Walker, M, Koopman, Anitra D, Tim J. McDonald, Barnett, Anna, Pearson, E, Koopman, AD, Koivula, R. W., Pearson, E., Koivula, Robert W., Heggie, Alison, McDonald, TJ, Koivula, Robert, Frost, G., Franks, PaulW., Rutters, F., Koopman, A. D., Perry, M.H., Heymans, M.W., Heggie, A, Ruetten, Hartmut, Simone Rauh, DIRECT Consortium (), Dekker, JM, Perry, MandyH., Hattersley, A., Koivula, R.W., Pearson, E. R., Franks, Paul, Herrgård, S, Franks, P. W., Vestergaard, H, Tue H. Hansen, Heymans, M. W., Koopman, AnitraD., Frost, Gary, Markku Laakso, Gary Frost, Gupta, Ramneek, Bell, J, Koopman, Anitra, Herrgård, Sanna, Teare, HJA, Dekker, Jacqueline M., Hattersley, Andrew, Hansen, Tue Haldor, Walker, M., Torben Hansen, Ridderstråle, M, Bell, Jimmy, Thorand, B, Brunak, S., Heymans, Martijn W, Søren Brunak, Laakso, M, Koopman, Anitra D., Koivisto, V., Mari, Andrea, Perry, Mandy H, Ridderstrale, M., Femke Rutters, Brunak, Soren, Pedersen, O., Hansen, Torben, Jacqueline M. Dekker, Perry, M. H., Gupta, R, Mari, A., Barbara Thorand, Teare, H. J. A., Koivisto, V, Mari, A, Dekker, JacquelineM., Koivula, RobertW., Walker, Mark, Oluf Pedersen, Franks, Paul,, Dekker, J.M., Siloaho, M, Ruetten, H., Cederberg, H, Koopman, A.D., Teare, HarrietJ.A., Pedersen, O, Dekker, J. M., Mandy H. Perry, Anitra D. Koopman, Martijn W. Heymans, Anna Barnett, Koivisto, Veikko, Laakso, Markku, Teare, H.J.A., Hansen, T. H., McDonald, TimJ., Henna Cederberg, Rauh, Simone, McDonald, Tim J, Gupta, R., Harriet J. A. Teare, Teare, H.J., Hartmut Ruetten, Jablonka, Bernd, Brunak, S, Bell, J.D., Andrew Hattersley, Franks, PW, Rutters, F, Vestergaard, Henrik, Hansen, T. V. O., Martin Ridderstråle, Robert W. Koivula, Thorand, B., Jablonka, B., Jimmy Bell, Koivula, Robert,, McDonald, Tim J., Perry, Mandy H., McDonald, Timothy J.   +176 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Prevalence of type 1 diabetes among children aged 0–14 in Australia 2013 [PDF]

, 2015
Prevalence of type 1 diabetes among children aged 0–14 in Australia 2013 presents the first national picture of children aged 0–14 living with type 1 diabetes in Australia.
Sarah Bullock, Karen Byng
core  

Ideas and Enhancements Related to Mobile Applications to Support Type 1 Diabetes [PDF]

, 2013
Background: Mobile devices have become increasingly important to young people who now use them to access a wide variety of health-related information. Research and policy related to the integration of health information and support with this technology ...
Masding, Mike, Pulman, Andy J., Galvin, Kathleen Theresa, Pulman, Andy, Galvin, Kathleen, Taylor-Jackson, Jacqui (R19920), Taylor, Jacqui, Masding, Mike G., Masding, M.G., Galvin, Kathleen T.   +9 more
core   +1 more source

TMEM219 regulates the transcription factor expression and proliferation of beta cells

Frontiers in Endocrinology
Pancreatic beta cells replenishment is considered the next therapeutic option for type 1 diabetes; while stimulating endogenous beta cells proliferation is the “holy grail” for those patients with exhausted beta cell mass.
Francesca D’Addio, Francesca D’Addio, Emma Assi, Anna Maestroni, Giada Rossi, Vera Usuelli, Adriana Petrazzuolo, Marta Nardini, Marta Nardini, Cristian Loretelli, Moufida Ben Nasr, Moufida Ben Nasr, Paolo Fiorina, Paolo Fiorina, Paolo Fiorina   +14 more
doaj   +1 more source