Results 81 to 90 of about 2,364,373 (300)

Impact of exercise-nutritional state interactions in patients with type 2 diabetes

, 2020
Introduction This study examines the role of nutritional status during exercise training in patients with type 2 diabetes mellitus by investigating the effect of endurance-type exercise training in the fasted versus the fed state on clinical outcome ...
Calders, Patrick, Celie, Bert, Dendale, Paul, Hansen, Dominique, Lapauw, Bruno, Stevens, An, van Loon, Luc JC, Vandenabeele, Frank, Verboven, Kenneth, Wens, Inez   +9 more
core   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

The emerging role of targeting cancer metabolism for cancer therapy

Tumor Biology, 2020
Glucose, as the main consuming nutrient of the body, faces different destinies in cancer cells. Glycolysis, oxidative phosphorylation, and pentose phosphate pathways produce different glucose-derived metabolites and thus affect cells’ bioenergetics ...
Pegah Farhadi, Reza Yarani, Sadat Dokaneheifard, Kamran Mansouri   +3 more
doaj   +1 more source

The lived experience of parents caring for a child with Type 1 diabetes : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Clinical Psychology at Massey University, Palmerston North, New Zealand [PDF]

, 2017
Type 1 diabetes is the most common chronic metabolic condition seen in children and adolescents. Parents of children with Type 1 diabetes are responsible for carrying out a demanding treatment regimen on a daily basis, to prevent short- and long-term ...
Rifshana, Fathimath
core  

When is diabetes distress clinically meaningful?: establishing cut points for the Diabetes Distress Scale. [PDF]

, 2012
ObjectiveTo identify the pattern of relationships between the 17-item Diabetes Distress Scale (DDS17) and diabetes variables to establish scale cut points for high distress among patients with type 2 diabetes.Research design and methodsRecruited were 506
Fisher, Lawrence, Hessler, Danielle M, Mullan, Joseph, Polonsky, William H   +3 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Human islet isolation and allotransplantation in 22 consecutive cases [PDF]

, 1992
This report provides our initial experience in islet isolation and intrahepatic allotransplantation in 21 patients. In group 1, 10 patients underwent combined liver-islet allotransplantation following upper-abdominal exenteration for cancer.
Alejandro, R, Carroll, PB, Demetris, AJ, Fung, JJ, Mintz, DH, Ricordi, C, Rodriguez Rilo, HL, Shapiro, R, Starzl, TE, Tzakis, AG, Zeng, Y   +10 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials [PDF]

, 2017
OBJECTIVE: We assessed dysglycemia and a T1D Diagnostic Index60 (Index60) ≥1.00 (on the basis of fasting C-peptide, 60-min glucose, and 60-min C-peptide levels) as prediagnostic end points for type 1 diabetes among Type 1 Diabetes TrialNet Pathway to ...
Atkinson, Mark A., Boulware, David, Colman, Peter, Evans-Molina, Carmella, Geyer, Susan, Goland, Robin, Moran, Antoinette, Nathan, Brandon M., Russell, William, Skyler, Jay S., Sosenko, Jay M., Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups, Wentworth, John M., Wherrett, Diane, Wilson, Darrell M.   +14 more
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source