Results 111 to 120 of about 2,796,719 (361)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Health Behaviour Change Techniques in Diabetes Management Applications: A Systematic Review [PDF]

arXiv, 2019
The rapid growth in mobile healthcare technology could significantly help control chronic diseases, such as diabetes. This paper presents a systematic review to characterise type 1 & type 2 diabetes management applications available in Apple's iTunes store.
arxiv  

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source

TMEM219 regulates the transcription factor expression and proliferation of beta cells

Frontiers in Endocrinology
Pancreatic beta cells replenishment is considered the next therapeutic option for type 1 diabetes; while stimulating endogenous beta cells proliferation is the “holy grail” for those patients with exhausted beta cell mass.
Francesca D’Addio, Francesca D’Addio, Emma Assi, Anna Maestroni, Giada Rossi, Vera Usuelli, Adriana Petrazzuolo, Marta Nardini, Marta Nardini, Cristian Loretelli, Moufida Ben Nasr, Moufida Ben Nasr, Paolo Fiorina, Paolo Fiorina, Paolo Fiorina   +14 more
doaj   +1 more source

Diabetes distress and marriage in Type-1 diabetes

Indian Journal of Community Medicine, 2018
In spite of the large number of people with Type-1 diabetes mellitus (T1DM) in India, India is not a diabetes-friendly society. The society suffers from lots of myths regarding diabetes and insulin use. This review highlights challenges faced by young people living with T1DM with regards to marriage, associated diabetes distress, and suggests potential
Lovely Gupta, Sanjay Kalra, Deepak Khandelwal, Deep Dutta, Priti Rishi Lal, Amit Kumar Vishwakarma   +5 more
openaire   +4 more sources

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

FEBS Open Bio, EarlyView.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma, Samar Kumar Basak, Sujata Das, Debasmita Pankaj Alone   +3 more
wiley   +1 more source

Supervised Machine Learning based Ensemble Model for Accurate Prediction of Type 2 Diabetes [PDF]

arXiv, 2019
According to the American Diabetes Association(ADA), 30.3 million people in the United States have diabetes, but only 7.2 million may be undiagnosed and unaware of their condition. Type 2 diabetes is usually diagnosed for most patients later on in life whereas the less common Type 1 diabetes is diagnosed early on in life.
arxiv  

Young people with type 1 diabetes and their transition to adult services. [PDF]

, 2013
More than 85% of children and young people with type 1 diabetes are not achieving the recommended target of
Kime, N
core   +1 more source

Positive feedback loop between MAPK and aquaporin 7 regulates autophagy and apoptosis induced by palmitate in RIN‐m5f cells

FEBS Open Bio, EarlyView.
T2DM is characterized by peripheral blood insulin resistance and progressive pancreatic β‐cell dysfunction. Here, we showed that AQP7, the only aquaglyceroporin protein, regulates autophagy and apoptosis in pancreatic β‐cells. We propose the existence of a positive feedback loop between MAPK signaling and AQP7 that regulates autophagy and apoptosis in ...
Maoqi Wang, Jiang Tan, Xueting He, Yuqin Chen, Guoping Qiu, Mei Yang   +5 more
wiley   +1 more source

'Join Us On Our Journey': developing a new model of care for children and young people with type 1 diabetes Final report for NHS Diabetes [PDF]

, 2012
The aims of this research were to develop a model of care that will deliver the aspirations of the policy document, ‘Making Every Young Person with Diabetes Matter’ and improve the care provision for children and young people with Type 1 diabetes in ...
Carlin, E, Kime, NH
core