Results 111 to 120 of about 2,420,770 (348)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Preventing the onset of diabetes with precision delivery of mesenchymal stem cells to the pancreas in a preclinical model

open access: yesStem Cell Research & Therapy
Background Mesenchymal stem cells (MSCs) represent a promising regenerative therapy associated with anti-inflammatory, anti-apoptotic, and pro-proliferative properties.
Reza Yarani   +7 more
doaj   +1 more source

Association Between Blood Pressure and Adverse Renal Events in Type 1 Diabetes. [PDF]

open access: yes, 2016
ObjectiveTo compare different blood pressure (BP) levels in their association with the risk of renal outcomes in type 1 diabetes and to determine whether an intensive glycemic control strategy modifies this association.Research design and methodsWe ...
Gitelman, Stephen E   +5 more
core   +2 more sources

Estrogen Deficiency Exacerbates Type 1 Diabetes–Induced Bone TNF-α Expression and Osteoporosis in Female Mice [PDF]

open access: bronze, 2017
Sandi Raehtz   +4 more
openalex   +1 more source

Assessment of Meal Anticipation for Improving Fully Automated Insulin Delivery in Adults With Type 1 Diabetes [PDF]

open access: bronze, 2023
José Garcia‐Tirado   +11 more
openalex   +1 more source

The role of lipid metabolism in neuronal senescence

open access: yesFEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari   +2 more
wiley   +1 more source

Obesity and diabetes in New Zealand [PDF]

open access: yes
Obesity is a risk factor for diabetes, cardiovascular disease, musculoskeletal disorders, and some cancers. Introduction It is estimated that 1.1 million adults are obese in New Zealand (that is, they have a BMI or Body Mass Index of 30 or more ...
Alexandra Marett
core  

Urinary excretion of RAS, BMP, and WNT pathway components in diabetic kidney disease. [PDF]

open access: yes, 2014
The renin-angiotensin system (RAS), bone morphogenetic protein (BMP), and WNT pathways are involved in pathogenesis of diabetic kidney disease (DKD).
Afkarian, Maryam   +5 more
core   +1 more source

The Diabetes Eating Problem Survey-Revised (DEPS-R) in a Greek Adult Population with Type 1 Diabetes Mellitus: Model Comparison Supporting a Single Factor Structure [PDF]

open access: gold, 2021
Calliope Karastogiannidou   +6 more
openalex   +1 more source

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