Results 71 to 80 of about 854,739 (262)

Obesity and diabetes in New Zealand [PDF]

Obesity is a risk factor for diabetes, cardiovascular disease, musculoskeletal disorders, and some cancers. Introduction It is estimated that 1.1 million adults are obese in New Zealand (that is, they have a BMI or Body Mass Index of 30 or more ...
Alexandra Marett
core  

Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α

Advanced Science, EarlyView.
NEU1, a key regulator of glycolysis, is markedly upregulated following DOX treatment. This upregulation is attributed to HIF1α’s transcriptional repression, requiring intricate interactions with NRF2. Increased NEU1 facilitates SIRT1 lysosomal degradation, contributing to aberrant glycolytic phenotype and cardiac damage.
Ting Gao, Yufeng Tang, Tao Zeng, Jie Wang, Xiaohui Zhang, Qingbo Liu, Xun Guan, Xinyu Tang, Guangping Lu, Jiahao Li, Mingrui Liu, Dongmei Zhang, Sixuan Lv, Junlian Gu   +13 more
wiley   +1 more source

Diabetes mellitus type 1

, 2014
Bacheloroppgave i sykepleie ...
Tøraasen, Lisa Vangen, Al-Sultan, Zainab   +1 more
openaire   +1 more source

Targeted Delivery of α‐ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes

Advanced Science, EarlyView.
The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng   +12 more
wiley   +1 more source

Особливості клінічного перебігу кандидозу слизової оболонки порожнини рота у хворих на цукровий діабет типу 1 [PDF]

, 2017
Вивчено розповсюдженість та особливості клінічного перебігу кандидозу слизової оболонки порожнини рота у хворих на цукровий діабет типу 1. Розглянуто вплив загальної соматичної патології на частоту виникнення кандидозного стоматиту у хворих на цукровий ...
Дудченко, М.О., Нідзельський, М.Я., Скрипников, П.М., Ступак, О.П.   +3 more
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Immunomodulation for type 1 diabetes mellitus

International Journal of Clinical Practice, 2010
Type 1 diabetes (T1D) is characterised by immune-mediated pancreatic islet beta-cell destruction. The initial immune response engenders secondary and tertiary responses which collectively result in impairment of beta-cell function, progressive destruction of beta-cells and consequent development of T1D. The process is insidious and may evolve over many
openaire   +3 more sources

Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus

Advanced Science, EarlyView.
Baicalin alleviates E. coli‐induced intestinal inflammation through dual mechanisms: direct inhibition of the TLR4/IRF/STAT signaling pathway to modulate macrophage polarization and antigen presentation, thereby regulating Th17/Treg cell differentiation; and microbiota‐mediated indirect effects via increasing Lactobacillus amylovorus abundance and ...
Shunfen Zhang, Ruqing Zhong, Miao Zhou, Kai Li, Huiyuan Lv, Huixin Wang, Ye Xu, Dadan Liu, Qiugang Ma, Liang Chen, Hongfu Zhang   +10 more
wiley   +1 more source

Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus [PDF]

, 2010
BACKGROUND: Diabetic nephropathy is a serious complication of diabetes mellitus and is associated with considerable morbidity and high mortality.
A Buja, A Helgadottir, A Subramanian, AE Teschendorff, Alexander P Maxwell, Andrew E Teschendorff, AS O'Connor, B He, B Krause, BH Ramsahoye, C Weigert, Christopher G Bell, D Ansell, D Ingrosso, DA Tregouet, David A Savage, EJ Richards, ER Seaquist, F Eckhardt, G Lund, H Al-Kateb, H Makino, HN Ibrahim, JD Storey, JF Navarro-Gonzalez, JJ Rogus, JT Leek, K Ichinose, M Bibikova, M Bibikova, M Quinn, MG Pezzolesi, MG Pezzolesi, MM Suzuki, MP Turunen, NM Goldenberg, P Katavetin, R Ihaka, R Lister, R Sladek, RA Irizarry, RC Gentleman, S Beck, S Saxonov, Stephan Beck, T Hastie, TA Down, TJ Ekstrom, TS Leak, U.S Renal Data System, Vardhman K Rakyan   +50 more
core   +4 more sources

Dehydroepiandrosterone in the type 1 diabetes mellitus

Endocrine Regulations, 2012
Dehydroepiandrosterone (DHEA) is believed to exert, besides others, positive effects on the insulin resistance or its secretion and glucose metabolism. There are several reports dealing with the DHEA levels and its effects in the type 2 diabetes mellitus, but less information is available on the type 1 diabetic subjects. Recently, a report dealing with
Hana Hruskovicova, Michaela Duskova, Martin Hill, Luboslav Stárka   +3 more
openaire   +3 more sources

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway

Advanced Science, EarlyView.
This study investigates the role of macrophage pyruvate carboxylase (PC) in atherosclerosis (AS) demonstrating that PC upregulation in macrophages promotes metabolism reprogramming to enhance inflammatory responses via the HIF‐1 signaling pathway.
Ling‐Na Zhao, Rui‐Ling Wang, Ran‐Xin Liu, Meng‐Ru Zheng, Li Zhao, Bao‐Feng Li, Jia‐Le Li, De‐Shen Liu, Xiao‐Xia He, Qin‐Bao Peng, Kai Li, Tian‐Xiao Lin, Ying‐Ying Liu, Sheng‐Ping He, Jun Lu, Shao‐Yi Zheng, Xiu Liu, Fang‐Ze Huang   +17 more
wiley   +1 more source