Results 81 to 90 of about 34,462,189 (209)

Magnesium Enhances Immune Clearance of P. gingivalis in Macrophages by Suppressing MCU‐Mediated Mitochondrial Calcium Overload

Cell Proliferation, EarlyView.
Magnesium restores macrophage clearance of P. gingivalis by inhibiting MCU‐mediated calcium overload. P. gingivalis is mainly phagocytosed by macrophages but escapes intracellular clearance via MCU‐mediated mitochondrial and cytosolic Ca2+ overload in periodontitis. The persistent P.
Dao‐Kun Deng, Meng‐Jie Su, Min‐Yi Zhang, Yu‐Jie Tan, Wenyao Kongling, Hong‐Yu Wang, Mei Xu, Shi‐Yu Liu, Xiao‐Tao He, Fa‐Ming Chen, Bei‐Min Tian, Xuan Li   +11 more
wiley   +1 more source

Investigating the Dynamics of Sex‐Structured Stock Assessment Models Under Sexual Size Dimorphism

Fisheries Management and Ecology, EarlyView.
ABSTRACT The integration of separate sexes in stock assessment models represents an advancement towards more realistic modeling of interactions between fisheries and target species. However, increased model complexity can also introduce additional uncertainty into the modeling process.
Francisco Izquierdo, Marta Cousido‐Rocha, Massimiliano Cardinale, Maria Grazia Pennino, Andreia V. Silva, Cristina Silva, Hugo Mendes, Santiago Cerviño   +7 more
wiley   +1 more source

Antigenic relationships among type-1 fimbriae of Enterobacteriaceae revealed by immuno-electronmicroscopy [PDF]

Journal of Medical Microbiology, 1987
Antigenic relationships among type-1 fimbriae of 40 strains of Enterobacteriaceae representing 19 species and seven genera were determined by immuno-electronmicroscopy. Ten distinct antigenic groups were distinguished. Intra- and inter-generic relationships were observed although some antigenic groups were species-specific only. Antigenic relationships
R A, Adegbola, D C, Old
openaire   +2 more sources

Additional sectioning and AI‐assisted diagnosis reveal underdiagnosis of serous (pre)malignancies in fallopian tube specimen from BRCA1/2 carriers

Histopathology, EarlyView.
This paper shows that deeper sections reveal additional STICs and HGSCs in risk‐reducing salpingo‐oophorectomy specimens of patients who did not have a STIC or HGSC diagnosis but did develop peritoneal HGSC 10 years after surgery. This adds to the premise that HGSC originates in the fallopian tube.
Anouk B Bouwmeester, Tamar A Gootzen, Marielle Nobbenhuis, Vilius Rudaitis, Caroline B van den Berg, Heleen J van Beekhuizen, Luthy SM Alcalá, Dineke PM Smedts, Nicole CM Visser, Viola Verhoef, Trudy GN Jonges, Ronald P Zweemer, Alicia Leon‐Catillo, Carlijn Lems, Joanne A de Hullu, Jeroen AWM van der Laak, Miranda P Steenbeek, Michiel Simons   +17 more
wiley   +1 more source

Uropathogenic Escherichia coli P and Type 1 fimbriae act in synergy in a living host to facilitate renal colonization leading to nephron obstruction. [PDF]

PLoS Pathogens, 2011
The progression of a natural bacterial infection is a dynamic process influenced by the physiological characteristics of the target organ. Recent developments in live animal imaging allow for the study of the dynamic microbe-host interplay in real-time ...
Keira Melican, Ruben M Sandoval, Abdul Kader, Lina Josefsson, George A Tanner, Bruce A Molitoris, Agneta Richter-Dahlfors   +6 more
doaj   +1 more source

Cutting Edge: FimH Adhesin of Type 1 Fimbriae Is a Novel TLR4 Ligand [PDF]

The Journal of Immunology, 2008
Abstract Several TLR ligands of bacterial origin induce innate immune responses. Although FimH, the adhesin portion of type 1 fimbria, plays an important role in the pathogenicity of some Gram-negative bacteria, its ability to stimulate the innate immune system via TLR signaling remains unclear.
Karen L, Mossman, M Firoz, Mian, Nicole M, Lauzon, Carlton L, Gyles, Brian, Lichty, Randy, Mackenzie, Navkiran, Gill, Ali A, Ashkar   +7 more
openaire   +2 more sources

Orchestrated molecular changes of proliferative, migratory‐fibrillar, synaptic, and postmigratory compartments align with precocious cortex‐type specification in the early human pallium

Journal of Anatomy, EarlyView.
Early human cortical development is organized by transient cellular compartments that define cortical types before mature layers form. Analysis of the human fetal pallium (7.5–15 PCW) shows distinct spatiotemporal trajectories for the archicortex, mesocortex, and neocortex, with delayed but accelerated differentiation in allocortical regions.
Janja Kopić, Fran Božić, Alisa Junaković Munjas, Željka Krsnik, Ivica Kostović   +4 more
wiley   +1 more source

Aerobic and anaerobic growth modes and expression of type 1 fimbriae in Salmonella

Pathophysiology, 2007
The aim of this study was to clarify the growth rates of facultatively anaerobic Salmonella enterica serovar Enteritidis strain in aerobic and anaerobic conditions and the expression of type 1 fimbriae in relation to the growth phases. The cultivation was carried out in a Portable Microbe Enrichment Unit (PMEU) where in same conditions one can grow the
Elias, Hakalehto, Jouni, Pesola, Lauri, Heitto, Ale, Närvänen, Anneli, Heitto   +4 more
openaire   +2 more sources

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Activation of the NLRP3 Inflammasome Pathway by Uropathogenic Escherichia coli Is Virulence Factor-Dependent and Influences Colonization of Bladder Epithelial Cells

Frontiers in Cellular and Infection Microbiology, 2018
The NLRP3 inflammasome and IL-1β release have recently been suggested to be important for the progression of urinary tract infection (UTI). However, much is still unknown regarding the interaction of UPEC and the NLRP3 inflammasome.
Isak Demirel, Isak Demirel, Alexander Persson, Alexander Persson, Annelie Brauner, Eva Särndahl, Eva Särndahl, Robert Kruse, Robert Kruse, Robert Kruse, Katarina Persson, Katarina Persson   +11 more
doaj   +1 more source