Results 121 to 130 of about 5,397,691 (379)

Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population [PDF]

, 2008
Background Recent studies have implicated variants of the transcription factor 7-like 2 (TCF7L2) gene in genetic susceptibility to type 2 diabetes mellitus in several different populations. The aim of this study was to determine whether variants of this
A Helgason, Abigail C Britten, AH Barnett, Anthony H Barnett, C Zhang, CM Damcott, GR Chandak, J Paul O'Hare, J Wang, JC Barrett, JC Florez, JC Florez, JV van Vliet-Ostaptchouk, LJ Scott, M Ann Kelly, R Saxena, R Zhang, RJ Loos, S Cauchi, S Cauchi, S Mayans, SE Humphries, SF Grant, Simon D Rees, Srikanth Bellary, Sudhesh Kumar, The International HapMap Consortium, U Smith, WHO Consultation   +28 more
core   +6 more sources

Association of SGLT2 Inhibitors With Cardiovascular and Kidney Outcomes in Patients With Type 2 Diabetes

JAMA cardiology, 2020
This meta-analysis uses data from patients with type 2 diabetes from 6 outcomes trials to investigate the association of sodium-glucose cotransporter 2 inhibitors with cardiovascular- and kidney disease–related outcomes.
D. McGuire, W. Shih, F. Cosentino, B. Charbonnel, D. Cherney, S. Dagogo-Jack, R. Pratley, Michelle Greenberg, Shuai Wang, S. Huyck, I. Gantz, S. Terra, Urszula Masiukiewicz, C. Cannon   +13 more
semanticscholar   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Type 2 diabetes: Challenges facing GPs

Family Medicine and Community Health, 2018
China faces a huge task in managing the large numbers of people with diabetes. Primary care is at the forefront of this challenge, and needs to begin to adopt some of the management and organizational approaches that have been shown to be successful in ...
Lili Huo, Jonathan E. Shaw
doaj   +1 more source

Risk Factors of Diabetes Mellitus in Rural Puducherry [PDF]

, 2012
Purpose: Prevalence of type 2 diabetes is increasing in India. Rural area constitutes 80% of India. Hence it is essential to understand the epidemiology for appropriate interventions.
Das, AK, Majgi, SM, Roy, G, Soudarssanane, BM   +3 more
core   +1 more source

Patient and provider acceptance of telecoaching in type 2 diabetes : a mixed-method study embedded in a randomised clinical trial [PDF]

, 2016
Background: Despite advances in diagnosis and treatment of type 2 diabetes, suboptimal metabolic control persists. Patient education in diabetes has been proved to enhance self-efficacy and guideline-driven treatment, however many people with type 2 ...
Aertgeerts, Bert, Annemans, Lieven, Buysse, Heidi, Goderis, Geert, Nobels, Frank, Odnoletkova, Irina, Ramaekers, Dirk   +6 more
core   +3 more sources

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source

Obesity and diabetes in New Zealand [PDF]

Obesity is a risk factor for diabetes, cardiovascular disease, musculoskeletal disorders, and some cancers. Introduction It is estimated that 1.1 million adults are obese in New Zealand (that is, they have a BMI or Body Mass Index of 30 or more ...
Alexandra Marett
core  

The impact of type 2 diabetes and Microalbuminuria on future cardiovascular events in patients with clinically manifest vascular disease from the Second Manifestations of ARTerial Disease (SMART) study [PDF]

, 2008
Aims Type 2 diabetes mellitus and microalbuminuria are important risk factors for cardiovascular disease (CVD). Whether these two complications are important and independent risk factors for future CVD events in a high-risk population with clinically ...
Algra, A., Graaf, Y., van der, Soedamah-Muthu, S.S., Visseren, F.L.J.   +3 more
core   +3 more sources

Mitochondrial DNA disorders in neuromuscular diseases in diverse populations

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Neuromuscular features are common in mitochondrial DNA (mtDNA) disorders. The genetic architecture of mtDNA disorders in diverse populations is poorly understood. We analysed mtDNA variants from whole‐exome sequencing data in neuromuscular patients from South Africa, Brazil, India, Turkey and Zambia. In 998 individuals, there were two definite
Fei Gao, Katherine R Schon, Jana Vandrovcova, Özlem Yayıcı Köken, Sharika Raga, Kireshnee Naidu, Maryke Schoonen, Nimita Rani, Pedro Tomaselli, Dipti Baskar, Musambo Kapapa, Ipek Polat, Lindsay A Wilson, Kumarasamy Thangaraj, Uluç Yiş, Bevinahalli N Nandeesh, David Bearden, Michelle Kvalsund, Franclo Henning, Seena Vengalil, Atchayaram Nalini, Claudia F. R. Sobreira, Wilson Marques, Haluk Topoloğlu, Michael G Hanna, Sireesha Yareeda, Venugopalan Y Vishnu, Francois H van der Westhuizen, Izelle Smuts, Surita Meldau, Jo Wilmshurst, Büşranur Çavdarlı, Jeannine Heckmann, Patrick F Chinnery, Rita Horvath   +34 more
wiley   +1 more source