Results 31 to 40 of about 2,540,555 (296)

Educational weight loss interventions in obese and overweight adults with type 2 diabetes : a systematic review and meta‐analysis of randomized controlled trials [PDF]

, 2020
Aim The worldwide prevalence of type 2 diabetes mellitus is increasing, with most individuals with the disease being overweight or obese. Weight loss can reduce disease‐related morbidity and mortality and weight losses of 10–15 kg have been shown to ...
Dhalwani, N., Griffiths, Frances, Kai, J., Kendrick, D., Khunti, K., Maula, A., Weng, S., Woolley, A. K.   +7 more
core   +3 more sources

Liraglutide and renal outcomes in type 2 diabetes [PDF]

, 2017
In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with type 2 diabetes and high cardiovascular risk who were receiving usual care, we found that liraglutide resulted in lower risks ...
Brown-Frandsen, Kirstine, Buse, John B., Mann, Johannes F. E, Maranghi, M., Marso, Steven P, Poulter, Neil R, Rasmussen, Søren, Tornøe, Karen, Zinman, Bernard, Ørsted, David D   +9 more
core   +2 more sources

Cohort profile: the ‘Biomarkers of heterogeneity in type 1 diabetes’ study—a national prospective cohort study of clinical and metabolic phenotyping of individuals with long-standing type 1 diabetes in the Netherlands

BMJ Open
Purpose The ‘Biomarkers of heterogeneity in type 1 diabetes’ study cohort was set up to identify genetic, physiological and psychosocial factors explaining the observed heterogeneity in disease progression and the development of complications in people ...
, Erwin Birnie, Giesje Nefs, Bruce H R Wolffenbuttel, Melanie M van der Klauw, Peter R van Dijk, Klaas Hoogenberg, Henk J Veeze, Henk-Jan Aanstoot, Bruce HR Wolffenbuttel, Charlotte E Vollenbrock, Pim Dekker, Lianne S M Boesten, Martine M C de Vries-Velraeds, Adriaan Kooy, Dick Mul, Sanjoy Dutta, Rita D M Varkevisser, Michael P Brugts, Petronella H L M Duijvestijn, Christine Fransman, Rob K Gonera, Esther Latres, Sandra Loves, Theo Sas, Marleen J Vosjan-Noeverman, Rita DM Varkevisser, Lianne SM Boesten, Peter R van Dijk, Petronella HLM Duijvestijn, Martine MC de Vries-Velraeds, Melanie M van der Klauw   +31 more
doaj   +1 more source

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes [PDF]

, 2016
Background The cardiovascular effect of liraglutide, a glucagon-like peptide 1 analogue, when added to standard care in patients with type 2 diabetes, remains unknown. Methods In this double-blind trial, we randomly assigned patients with type 2 diabetes
Bergenstal, RM, Brown-Frandsen, K, Buse, JB, Daniels, GH, Kristensen, P, LEADER Steering Committee on behalf of the LEADER Trial Investigators, Mann, JF, Marso, SP, Nauck, MA, Nissen, SE, Pocock, S, Poulter, NR, Ravn, LS, Steinberg, WM, Stockner, M, Zinman, B   +15 more
core   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b

Cellular & Molecular Biology Letters
Background The trafficking of cargoes from endosomes to the trans-Golgi network requires numerous sequential and coordinated steps. Cargoes are sorted into endosomal-derived carriers that are transported, tethered, and fused to the trans-Golgi network ...
Jérôme Gilleron, Abderrahman Chafik, Sandra Lacas-Gervais, Jean-François Tanti, Mireille Cormont   +4 more
doaj   +1 more source

β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency. [PDF]

, 2010
ObjectiveThe islet in type 2 diabetes is characterized by β-cell apoptosis, β-cell endoplasmic reticulum stress, and islet amyloid deposits derived from islet amyloid polypeptide (IAPP).
Butler, Alexandra E, Butler, Peter C, Costes, Safia, Daval, Marie, Gurlo, Tatyana, Huang, Chang-jiang, Matveyenko, Aleksey V, Rizza, Robert A   +7 more
core   +2 more sources

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

MicroRNAs and type 2 diabetes

ExRNA, 2019
MicroRNAs (miRNAs) are non-coding single strand RNAs. MiRNAs are encoded by endogenous genes with a length of about 22 nucleotides. MiRNAs play a vital role in the inhibition of post-transcriptional translation of mRNAs.
Jiali Deng, Feifan Guo
doaj   +1 more source

Dyslipidemia in type 2 diabetes mellitus [PDF]

Arhiv za farmaciju, 2019
Type 2 diabetes mellitus is a chronic high-prevalence metabolic disease, which is characterized by hyperglycaemia, but also with lipid and protein metabolism disorders.
Stefanović Aleksandra, Zeljković Aleksandra, Vekić Jelena, Spasojević-Kalimanovska Vesna, Jelić-Ivanović Zorana, Spasić Slavica   +5 more
doaj   +1 more source